Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular disea...

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Autores principales:	Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, Mohsen Ghanbari, Peter J. van der Most, Rui Climaco Pinto, Matthias Wielscher, Matthias Farlik, Verena Zuber, Robert J. de Knegt, Harold Snieder, André G. Uitterlinden, Lifelines Cohort Study, Julie A. Lynch, Xiyun Jiang, Saredo Said, David E. Kaplan, Kyung Min Lee, Marina Serper, Rotonya M. Carr, Philip S. Tsao, Stephen R. Atkinson, Abbas Dehghan, Ioanna Tzoulaki, M. Arfan Ikram, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Behrooz Z. Alizadeh, Christopher J. O’Donnell, Danish Saleheen, Benjamin F. Voight, Kyong-Mi Chang, Mark R. Thursz, Paul Elliott, the VA Million Veteran Program
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4be589280cfe4d8ca12d31bf23d6016e
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spelling	oai:doaj.org-article:4be589280cfe4d8ca12d31bf23d6016e2021-12-02T16:57:12ZGenetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes10.1038/s41467-021-22338-22041-1723https://doaj.org/article/4be589280cfe4d8ca12d31bf23d6016e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22338-2https://doaj.org/toc/2041-1723Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.Raha PazokiMarijana VujkovicJoshua ElliottEvangelos EvangelouDipender GillMohsen GhanbariPeter J. van der MostRui Climaco PintoMatthias WielscherMatthias FarlikVerena ZuberRobert J. de KnegtHarold SniederAndré G. UitterlindenLifelines Cohort StudyJulie A. LynchXiyun JiangSaredo SaidDavid E. KaplanKyung Min LeeMarina SerperRotonya M. CarrPhilip S. TsaoStephen R. AtkinsonAbbas DehghanIoanna TzoulakiM. Arfan IkramKarl-Heinz HerzigMarjo-Riitta JärvelinBehrooz Z. AlizadehChristopher J. O’DonnellDanish SaleheenBenjamin F. VoightKyong-Mi ChangMark R. ThurszPaul Elliottthe VA Million Veteran ProgramNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raha Pazoki Marijana Vujkovic Joshua Elliott Evangelos Evangelou Dipender Gill Mohsen Ghanbari Peter J. van der Most Rui Climaco Pinto Matthias Wielscher Matthias Farlik Verena Zuber Robert J. de Knegt Harold Snieder André G. Uitterlinden Lifelines Cohort Study Julie A. Lynch Xiyun Jiang Saredo Said David E. Kaplan Kyung Min Lee Marina Serper Rotonya M. Carr Philip S. Tsao Stephen R. Atkinson Abbas Dehghan Ioanna Tzoulaki M. Arfan Ikram Karl-Heinz Herzig Marjo-Riitta Järvelin Behrooz Z. Alizadeh Christopher J. O’Donnell Danish Saleheen Benjamin F. Voight Kyong-Mi Chang Mark R. Thursz Paul Elliott the VA Million Veteran Program Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
description	Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.
format	article
author	Raha Pazoki Marijana Vujkovic Joshua Elliott Evangelos Evangelou Dipender Gill Mohsen Ghanbari Peter J. van der Most Rui Climaco Pinto Matthias Wielscher Matthias Farlik Verena Zuber Robert J. de Knegt Harold Snieder André G. Uitterlinden Lifelines Cohort Study Julie A. Lynch Xiyun Jiang Saredo Said David E. Kaplan Kyung Min Lee Marina Serper Rotonya M. Carr Philip S. Tsao Stephen R. Atkinson Abbas Dehghan Ioanna Tzoulaki M. Arfan Ikram Karl-Heinz Herzig Marjo-Riitta Järvelin Behrooz Z. Alizadeh Christopher J. O’Donnell Danish Saleheen Benjamin F. Voight Kyong-Mi Chang Mark R. Thursz Paul Elliott the VA Million Veteran Program
author_facet	Raha Pazoki Marijana Vujkovic Joshua Elliott Evangelos Evangelou Dipender Gill Mohsen Ghanbari Peter J. van der Most Rui Climaco Pinto Matthias Wielscher Matthias Farlik Verena Zuber Robert J. de Knegt Harold Snieder André G. Uitterlinden Lifelines Cohort Study Julie A. Lynch Xiyun Jiang Saredo Said David E. Kaplan Kyung Min Lee Marina Serper Rotonya M. Carr Philip S. Tsao Stephen R. Atkinson Abbas Dehghan Ioanna Tzoulaki M. Arfan Ikram Karl-Heinz Herzig Marjo-Riitta Järvelin Behrooz Z. Alizadeh Christopher J. O’Donnell Danish Saleheen Benjamin F. Voight Kyong-Mi Chang Mark R. Thursz Paul Elliott the VA Million Veteran Program
author_sort	Raha Pazoki
title	Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
title_short	Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
title_full	Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
title_fullStr	Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
title_full_unstemmed	Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
title_sort	genetic analysis in european ancestry individuals identifies 517 loci associated with liver enzymes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4be589280cfe4d8ca12d31bf23d6016e
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Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

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