Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

Mitochondria, a kind of subcellular organelle, play crucial roles in cancer cells as an energy source and as a generator of reactive substrates, which concern the generation, proliferation, drug resistance, and other functions of cancer. Therefore, precise delivery of anticancer agents to mitochondr...

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Autores principales:	Tingting Hu, Zhou Qin, Chao Shen, Han-Lin Gong, Zhi-Yao He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondria targeted drug delivery systems liposomes nanoparticles nanomicelles Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/4bedfaf3c302482984fdeceabdc4a5c1
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spelling	oai:doaj.org-article:4bedfaf3c302482984fdeceabdc4a5c12021-11-30T18:36:57ZMultifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy2296-418510.3389/fbioe.2021.786621https://doaj.org/article/4bedfaf3c302482984fdeceabdc4a5c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.786621/fullhttps://doaj.org/toc/2296-4185Mitochondria, a kind of subcellular organelle, play crucial roles in cancer cells as an energy source and as a generator of reactive substrates, which concern the generation, proliferation, drug resistance, and other functions of cancer. Therefore, precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Mitochondria have a four-layer structure with a high negative potential, which thereby prevents many molecules from reaching the mitochondria. Luckily, the advances in nanosystems have provided enormous hope to overcome this challenge. These nanosystems include liposomes, nanoparticles, and nanomicelles. Here, we summarize the very latest developments in mitochondria-targeting nanomedicines in cancer treatment as well as focus on designing multifunctional mitochondria-targeting nanosystems based on the latest nanotechnology.Tingting HuZhou QinChao ShenHan-Lin GongZhi-Yao HeZhi-Yao HeFrontiers Media S.A.articlemitochondriatargeted drug delivery systemsliposomesnanoparticlesnanomicellesBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria targeted drug delivery systems liposomes nanoparticles nanomicelles Biotechnology TP248.13-248.65
spellingShingle	mitochondria targeted drug delivery systems liposomes nanoparticles nanomicelles Biotechnology TP248.13-248.65 Tingting Hu Zhou Qin Chao Shen Han-Lin Gong Zhi-Yao He Zhi-Yao He Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
description	Mitochondria, a kind of subcellular organelle, play crucial roles in cancer cells as an energy source and as a generator of reactive substrates, which concern the generation, proliferation, drug resistance, and other functions of cancer. Therefore, precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Mitochondria have a four-layer structure with a high negative potential, which thereby prevents many molecules from reaching the mitochondria. Luckily, the advances in nanosystems have provided enormous hope to overcome this challenge. These nanosystems include liposomes, nanoparticles, and nanomicelles. Here, we summarize the very latest developments in mitochondria-targeting nanomedicines in cancer treatment as well as focus on designing multifunctional mitochondria-targeting nanosystems based on the latest nanotechnology.
format	article
author	Tingting Hu Zhou Qin Chao Shen Han-Lin Gong Zhi-Yao He Zhi-Yao He
author_facet	Tingting Hu Zhou Qin Chao Shen Han-Lin Gong Zhi-Yao He Zhi-Yao He
author_sort	Tingting Hu
title	Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
title_short	Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
title_full	Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
title_fullStr	Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
title_full_unstemmed	Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy
title_sort	multifunctional mitochondria-targeting nanosystems for enhanced anticancer efficacy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4bedfaf3c302482984fdeceabdc4a5c1
work_keys_str_mv	AT tingtinghu multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy AT zhouqin multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy AT chaoshen multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy AT hanlingong multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy AT zhiyaohe multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy AT zhiyaohe multifunctionalmitochondriatargetingnanosystemsforenhancedanticancerefficacy
_version_	1718406320805117952

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

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