A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus

ABSTRACT This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that this project will lead to a licensed...

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Autor principal:	Gregory D. Koblentz
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	DNA synthesis biosecurity dual use research horsepox smallpox synthetic biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4bef3bf26b4f43c684567082bff502ba
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spelling	oai:doaj.org-article:4bef3bf26b4f43c684567082bff502ba2021-11-15T15:22:14ZA Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus10.1128/mSphere.00040-182379-5042https://doaj.org/article/4bef3bf26b4f43c684567082bff502ba2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00040-18https://doaj.org/toc/2379-5042ABSTRACT This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that this project will lead to a licensed medical countermeasure. The combination of questionable benefits and known risks of this dual use research raises serious questions about the wisdom of undertaking research that could be used to recreate variola virus. This analysis also raises important questions about the propriety of a private company sponsoring such dual use research without appropriate oversight and highlights an important gap in United States dual use research regulations.Gregory D. KoblentzAmerican Society for MicrobiologyarticleDNA synthesisbiosecuritydual use researchhorsepoxsmallpoxsynthetic biologyMicrobiologyQR1-502ENmSphere, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA synthesis biosecurity dual use research horsepox smallpox synthetic biology Microbiology QR1-502
spellingShingle	DNA synthesis biosecurity dual use research horsepox smallpox synthetic biology Microbiology QR1-502 Gregory D. Koblentz A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
description	ABSTRACT This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that this project will lead to a licensed medical countermeasure. The combination of questionable benefits and known risks of this dual use research raises serious questions about the wisdom of undertaking research that could be used to recreate variola virus. This analysis also raises important questions about the propriety of a private company sponsoring such dual use research without appropriate oversight and highlights an important gap in United States dual use research regulations.
format	article
author	Gregory D. Koblentz
author_facet	Gregory D. Koblentz
author_sort	Gregory D. Koblentz
title	A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
title_short	A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
title_full	A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
title_fullStr	A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
title_full_unstemmed	A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus
title_sort	critical analysis of the scientific and commercial rationales for the <italic toggle="yes">de novo</italic> synthesis of horsepox virus
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/4bef3bf26b4f43c684567082bff502ba
work_keys_str_mv	AT gregorydkoblentz acriticalanalysisofthescientificandcommercialrationalesfortheitalictoggleyesdenovoitalicsynthesisofhorsepoxvirus AT gregorydkoblentz criticalanalysisofthescientificandcommercialrationalesfortheitalictoggleyesdenovoitalicsynthesisofhorsepoxvirus
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A Critical Analysis of the Scientific and Commercial Rationales for the <italic toggle="yes">De Novo</italic> Synthesis of Horsepox Virus

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