A combined experimental and modelling approach for the Weimberg pathway optimisation

Metabolic engineering is often hampered by non-linear kinetics and allosteric regulatory mechanisms. Here, the authors construct a quantitative model for the pentose degradation Weimberg pathway in Caulobacter crescentus and demonstrate its biotechnological applications in cell-free system and stand...

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Autores principales:	Lu Shen, Martha Kohlhaas, Junichi Enoki, Roland Meier, Bernhard Schönenberger, Roland Wohlgemuth, Robert Kourist, Felix Niemeyer, David van Niekerk, Christopher Bräsen, Jochen Niemeyer, Jacky Snoep, Bettina Siebers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bef7f520d5a46eab6a729fa78bb1433
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spelling	oai:doaj.org-article:4bef7f520d5a46eab6a729fa78bb14332021-12-02T16:56:32ZA combined experimental and modelling approach for the Weimberg pathway optimisation10.1038/s41467-020-14830-y2041-1723https://doaj.org/article/4bef7f520d5a46eab6a729fa78bb14332020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14830-yhttps://doaj.org/toc/2041-1723Metabolic engineering is often hampered by non-linear kinetics and allosteric regulatory mechanisms. Here, the authors construct a quantitative model for the pentose degradation Weimberg pathway in Caulobacter crescentus and demonstrate its biotechnological applications in cell-free system and standard metabolic engineering.Lu ShenMartha KohlhaasJunichi EnokiRoland MeierBernhard SchönenbergerRoland WohlgemuthRobert KouristFelix NiemeyerDavid van NiekerkChristopher BräsenJochen NiemeyerJacky SnoepBettina SiebersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Shen Martha Kohlhaas Junichi Enoki Roland Meier Bernhard Schönenberger Roland Wohlgemuth Robert Kourist Felix Niemeyer David van Niekerk Christopher Bräsen Jochen Niemeyer Jacky Snoep Bettina Siebers A combined experimental and modelling approach for the Weimberg pathway optimisation
description	Metabolic engineering is often hampered by non-linear kinetics and allosteric regulatory mechanisms. Here, the authors construct a quantitative model for the pentose degradation Weimberg pathway in Caulobacter crescentus and demonstrate its biotechnological applications in cell-free system and standard metabolic engineering.
format	article
author	Lu Shen Martha Kohlhaas Junichi Enoki Roland Meier Bernhard Schönenberger Roland Wohlgemuth Robert Kourist Felix Niemeyer David van Niekerk Christopher Bräsen Jochen Niemeyer Jacky Snoep Bettina Siebers
author_facet	Lu Shen Martha Kohlhaas Junichi Enoki Roland Meier Bernhard Schönenberger Roland Wohlgemuth Robert Kourist Felix Niemeyer David van Niekerk Christopher Bräsen Jochen Niemeyer Jacky Snoep Bettina Siebers
author_sort	Lu Shen
title	A combined experimental and modelling approach for the Weimberg pathway optimisation
title_short	A combined experimental and modelling approach for the Weimberg pathway optimisation
title_full	A combined experimental and modelling approach for the Weimberg pathway optimisation
title_fullStr	A combined experimental and modelling approach for the Weimberg pathway optimisation
title_full_unstemmed	A combined experimental and modelling approach for the Weimberg pathway optimisation
title_sort	combined experimental and modelling approach for the weimberg pathway optimisation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4bef7f520d5a46eab6a729fa78bb1433
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A combined experimental and modelling approach for the Weimberg pathway optimisation

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