Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.

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Detalles Bibliográficos
Autores principales: Na Zhao, Reid T. Powell, Xueying Yuan, Goeun Bae, Kevin P. Roarty, Fabio Stossi, Martina Strempfl, Michael J. Toneff, Hannah L. Johnson, Sendurai A. Mani, Philip Jones, Clifford C. Stephan, Jeffrey M. Rosen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c8
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Descripción
Sumario:The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.

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