Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.

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Autores principales:	Na Zhao, Reid T. Powell, Xueying Yuan, Goeun Bae, Kevin P. Roarty, Fabio Stossi, Martina Strempfl, Michael J. Toneff, Hannah L. Johnson, Sendurai A. Mani, Philip Jones, Clifford C. Stephan, Jeffrey M. Rosen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c8
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spelling	oai:doaj.org-article:4bf1f86424d4458c89d66da69cca86c82021-12-02T17:01:29ZMorphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition10.1038/s41467-021-24545-32041-1723https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24545-3https://doaj.org/toc/2041-1723The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.Na ZhaoReid T. PowellXueying YuanGoeun BaeKevin P. RoartyFabio StossiMartina StrempflMichael J. ToneffHannah L. JohnsonSendurai A. ManiPhilip JonesClifford C. StephanJeffrey M. RosenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Na Zhao Reid T. Powell Xueying Yuan Goeun Bae Kevin P. Roarty Fabio Stossi Martina Strempfl Michael J. Toneff Hannah L. Johnson Sendurai A. Mani Philip Jones Clifford C. Stephan Jeffrey M. Rosen Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
description	The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.
format	article
author	Na Zhao Reid T. Powell Xueying Yuan Goeun Bae Kevin P. Roarty Fabio Stossi Martina Strempfl Michael J. Toneff Hannah L. Johnson Sendurai A. Mani Philip Jones Clifford C. Stephan Jeffrey M. Rosen
author_facet	Na Zhao Reid T. Powell Xueying Yuan Goeun Bae Kevin P. Roarty Fabio Stossi Martina Strempfl Michael J. Toneff Hannah L. Johnson Sendurai A. Mani Philip Jones Clifford C. Stephan Jeffrey M. Rosen
author_sort	Na Zhao
title	Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
title_short	Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
title_full	Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
title_fullStr	Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
title_full_unstemmed	Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
title_sort	morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c8
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Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

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