Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training

Strength training increases systemic oxygen consumption, causing the excessive generation of reactive oxygen species, which in turn, provokes oxidative stress reactions and cellular processes that induce uterine contraction. The aim of this study was to evaluate the possible protective effect of <...

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Autores principales: Paula Benvindo Ferreira, Anderson Fellyp Avelino Diniz, Francisco Fernandes Lacerda Júnior, Maria da Conceição Correia Silva, Glêbia Alexa Cardoso, Alexandre Sérgio Silva, Bagnólia Araújo da Silva
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:4bf4898919994252b899798cd7d5218e2021-11-25T18:33:51ZSupplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training10.3390/nu131137632072-6643https://doaj.org/article/4bf4898919994252b899798cd7d5218e2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3763https://doaj.org/toc/2072-6643Strength training increases systemic oxygen consumption, causing the excessive generation of reactive oxygen species, which in turn, provokes oxidative stress reactions and cellular processes that induce uterine contraction. The aim of this study was to evaluate the possible protective effect of <i>Spirulina platensis</i> (SP), an antioxidant blue algae, on the contractile and relaxation reactivity of rat uterus and the balance of oxidative stress/antioxidant defenses. Female Wistar rats were divided into sedentary (CG), trained (TG), and T + supplemented (TG50, TG100) groups. Reactivity was analyzed by AQCAD, oxidative stress was evaluated by the malondialdehyde (MDA) formation, and the antioxidant capacity was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Strength training increased contractile reactivity and decreased the pharmaco-mechanical component of relaxing reactivity in rat uterus. In addition, training decreased oxidation inhibition in the plasma and exercise increased oxidative stress in the uterine tissue; however, supplementation with algae prevented this effect and potentiated the increase in antioxidant capacity. Therefore, this study demonstrated that food supplementation prevents changes in reactivity and oxidative stress induced by strength training in a rat uterus, showing for the first time, that the uterus is a target for this exercise modality and antioxidant supplementation with <i>S. platensis</i> is an alternative means of preventing uterine dysfunction.Paula Benvindo FerreiraAnderson Fellyp Avelino DinizFrancisco Fernandes Lacerda JúniorMaria da Conceição Correia SilvaGlêbia Alexa CardosoAlexandre Sérgio SilvaBagnólia Araújo da SilvaMDPI AGarticle<i>Spirulina platensis</i>physical exerciseuterusoxidative stressmuscle reactivityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3763, p 3763 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Spirulina platensis</i>
physical exercise
uterus
oxidative stress
muscle reactivity
Nutrition. Foods and food supply
TX341-641
spellingShingle <i>Spirulina platensis</i>
physical exercise
uterus
oxidative stress
muscle reactivity
Nutrition. Foods and food supply
TX341-641
Paula Benvindo Ferreira
Anderson Fellyp Avelino Diniz
Francisco Fernandes Lacerda Júnior
Maria da Conceição Correia Silva
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Bagnólia Araújo da Silva
Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
description Strength training increases systemic oxygen consumption, causing the excessive generation of reactive oxygen species, which in turn, provokes oxidative stress reactions and cellular processes that induce uterine contraction. The aim of this study was to evaluate the possible protective effect of <i>Spirulina platensis</i> (SP), an antioxidant blue algae, on the contractile and relaxation reactivity of rat uterus and the balance of oxidative stress/antioxidant defenses. Female Wistar rats were divided into sedentary (CG), trained (TG), and T + supplemented (TG50, TG100) groups. Reactivity was analyzed by AQCAD, oxidative stress was evaluated by the malondialdehyde (MDA) formation, and the antioxidant capacity was measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Strength training increased contractile reactivity and decreased the pharmaco-mechanical component of relaxing reactivity in rat uterus. In addition, training decreased oxidation inhibition in the plasma and exercise increased oxidative stress in the uterine tissue; however, supplementation with algae prevented this effect and potentiated the increase in antioxidant capacity. Therefore, this study demonstrated that food supplementation prevents changes in reactivity and oxidative stress induced by strength training in a rat uterus, showing for the first time, that the uterus is a target for this exercise modality and antioxidant supplementation with <i>S. platensis</i> is an alternative means of preventing uterine dysfunction.
format article
author Paula Benvindo Ferreira
Anderson Fellyp Avelino Diniz
Francisco Fernandes Lacerda Júnior
Maria da Conceição Correia Silva
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Bagnólia Araújo da Silva
author_facet Paula Benvindo Ferreira
Anderson Fellyp Avelino Diniz
Francisco Fernandes Lacerda Júnior
Maria da Conceição Correia Silva
Glêbia Alexa Cardoso
Alexandre Sérgio Silva
Bagnólia Araújo da Silva
author_sort Paula Benvindo Ferreira
title Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
title_short Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
title_full Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
title_fullStr Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
title_full_unstemmed Supplementation with <i>Spirulina platensis</i> Prevents Uterine Diseases Related to Muscle Reactivity and Oxidative Stress in Rats Undergoing Strength Training
title_sort supplementation with <i>spirulina platensis</i> prevents uterine diseases related to muscle reactivity and oxidative stress in rats undergoing strength training
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/4bf4898919994252b899798cd7d5218e
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