CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS

Food allergy against cow milk and its components is highly prevalent among infants and children of pre-school and young school age being a sufficient factor influencing health condition of children during the maturation period. Clinical signs of the milk allergy are non-specific, and they may be pro...

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Autores principales:	N. A. Alkhutova, N. A. Kovyazina, O. L. Zhizhina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	food allergies cow’s milk components specific ige intensity of allergic reaction pediatrics Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4bf99935e48746bda1daa5f3be21ac30
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spelling	oai:doaj.org-article:4bf99935e48746bda1daa5f3be21ac302021-11-18T08:03:48ZCLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS1563-06252313-741X10.15789/1563-0625-2019-5-937-944https://doaj.org/article/4bf99935e48746bda1daa5f3be21ac302019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1624https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFood allergy against cow milk and its components is highly prevalent among infants and children of pre-school and young school age being a sufficient factor influencing health condition of children during the maturation period. Clinical signs of the milk allergy are non-specific, and they may be pronounced or expressed in mild form, thus enabling hypodiagnistics of this disorder. Moreover, a variety of milk antigens determines different clinical course of this allergic condition and brings additional difficulties to its diagnostics and treatment. Meanwhile, a sensibilization for the cow milk proteins may sometimes trigger a generalized atopy and bronchial asthma, being a factor delayed growth and other health disorders. At the present time, there are no distinct risk criteria for milk allergy. Therefore, its successful prophylaxis and treatment largely depends on the competence of clinical allergologist and informativity of the diagnostic techniques used. So far, however, we have no generally approved laboratory algorithms for diagnostics and monitoring of treatment efficiency in the cow milk allergy and its compomemts.We have performed a laboratory study of 187 children at the age of 3 months to 10 years. An immunochemoluminescent assay of specific IgE antibody levels to the cow milk using IMMULITE 2000/XPi analyzer has revealed its good informative value at different approaches to prediction and evaluation of food allergy treatment, both oriented for a critical cutoff value of 3 МU/L, and by monitoring a decrease in antibody levels. The authors consider rational an extended indefinity principle during the patient-oriented interpretation of IgE assay results if clinical decision is based on critical value of the index. In cases of clinical monitoring, the limit of interim reproducibility should be taken into account. The prevalence of specific cow milk antibodies among the boys was higher than among girls, however, with lesser frequency of moderate/high reactivity among the males. Moreover. the cases were detected with higher levels of anti-beta-lactalbumin IgG than those against whole milk. This finding should be considered during the screening studies.On the basis of literature analysis and own results, the authors propose an extensive study of specific IgE antibodies against cow milk and its components in blood serum of infants and children form the pre-school and junior school age groups.N. A. AlkhutovaN. A. KovyazinaO. L. ZhizhinaSPb RAACIarticlefood allergiescow’s milk componentsspecific igeintensity of allergic reactionpediatricsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 937-944 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	food allergies cow’s milk components specific ige intensity of allergic reaction pediatrics Immunologic diseases. Allergy RC581-607
spellingShingle	food allergies cow’s milk components specific ige intensity of allergic reaction pediatrics Immunologic diseases. Allergy RC581-607 N. A. Alkhutova N. A. Kovyazina O. L. Zhizhina CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
description	Food allergy against cow milk and its components is highly prevalent among infants and children of pre-school and young school age being a sufficient factor influencing health condition of children during the maturation period. Clinical signs of the milk allergy are non-specific, and they may be pronounced or expressed in mild form, thus enabling hypodiagnistics of this disorder. Moreover, a variety of milk antigens determines different clinical course of this allergic condition and brings additional difficulties to its diagnostics and treatment. Meanwhile, a sensibilization for the cow milk proteins may sometimes trigger a generalized atopy and bronchial asthma, being a factor delayed growth and other health disorders. At the present time, there are no distinct risk criteria for milk allergy. Therefore, its successful prophylaxis and treatment largely depends on the competence of clinical allergologist and informativity of the diagnostic techniques used. So far, however, we have no generally approved laboratory algorithms for diagnostics and monitoring of treatment efficiency in the cow milk allergy and its compomemts.We have performed a laboratory study of 187 children at the age of 3 months to 10 years. An immunochemoluminescent assay of specific IgE antibody levels to the cow milk using IMMULITE 2000/XPi analyzer has revealed its good informative value at different approaches to prediction and evaluation of food allergy treatment, both oriented for a critical cutoff value of 3 МU/L, and by monitoring a decrease in antibody levels. The authors consider rational an extended indefinity principle during the patient-oriented interpretation of IgE assay results if clinical decision is based on critical value of the index. In cases of clinical monitoring, the limit of interim reproducibility should be taken into account. The prevalence of specific cow milk antibodies among the boys was higher than among girls, however, with lesser frequency of moderate/high reactivity among the males. Moreover. the cases were detected with higher levels of anti-beta-lactalbumin IgG than those against whole milk. This finding should be considered during the screening studies.On the basis of literature analysis and own results, the authors propose an extensive study of specific IgE antibodies against cow milk and its components in blood serum of infants and children form the pre-school and junior school age groups.
format	article
author	N. A. Alkhutova N. A. Kovyazina O. L. Zhizhina
author_facet	N. A. Alkhutova N. A. Kovyazina O. L. Zhizhina
author_sort	N. A. Alkhutova
title	CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
title_short	CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
title_full	CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
title_fullStr	CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
title_full_unstemmed	CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS
title_sort	clinical and laboratory aspects of detecting specific ige antibodies to cow’s milk and its components
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/4bf99935e48746bda1daa5f3be21ac30
work_keys_str_mv	AT naalkhutova clinicalandlaboratoryaspectsofdetectingspecificigeantibodiestocowsmilkanditscomponents AT nakovyazina clinicalandlaboratoryaspectsofdetectingspecificigeantibodiestocowsmilkanditscomponents AT olzhizhina clinicalandlaboratoryaspectsofdetectingspecificigeantibodiestocowsmilkanditscomponents
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CLINICAL AND LABORATORY ASPECTS OF DETECTING SPECIFIC IgE ANTIBODIES TO COW’S MILK AND ITS COMPONENTS

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