Applications of gold nanoparticles in cancer nanotechnology

Weibo Cai1,2, Ting Gao3, Hao Hong1, Jiangtao Sun11Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin &ndash; Madison, Madison, Wisconsin, USA; 2University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, US...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weibo Cai, Ting Gao, Hao Hong, Jiangtao Sun
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/4bfbb53a47ce4ec998e992b83b2d0b69
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4bfbb53a47ce4ec998e992b83b2d0b69
record_format	dspace
spelling	oai:doaj.org-article:4bfbb53a47ce4ec998e992b83b2d0b692021-12-02T04:05:12ZApplications of gold nanoparticles in cancer nanotechnology1177-8903https://doaj.org/article/4bfbb53a47ce4ec998e992b83b2d0b692008-09-01T00:00:00Zhttp://www.dovepress.com/applications-of-gold-nanoparticles-in-cancer-nanotechnology-a2253https://doaj.org/toc/1177-8903Weibo Cai1,2, Ting Gao3, Hao Hong1, Jiangtao Sun11Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin &ndash; Madison, Madison, Wisconsin, USA; 2University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA; 3Tyco Electronics Corporation, 306 Constitution Drive, Menlo Park, California, USAAbstract: It has been almost 4 decades since the &ldquo;war on cancer&rdquo; was declared. It is now generally believed that personalized medicine is the future for cancer patient management. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of cancer, nanoparticles have been extensively studied over the last decade. In this review, we will summarize the current state-of-the-art of gold nanoparticles in biomedical applications targeting cancer. Gold nanospheres, nanorods, nanoshells, nanocages, and surface enhanced Raman scattering nanoparticles will be discussed in detail regarding their uses in in vitro assays, ex vivo and in vivo imaging, cancer therapy, and drug delivery. Multifunctionality is the key feature of nanoparticle-based agents. Targeting ligands, imaging labels, therapeutic drugs, and other functionalities can all be integrated to allow for targeted molecular imaging and molecular therapy of cancer. Big strides have been made and many proof-of-principle studies have been successfully performed. The future looks brighter than ever yet many hurdles remain to be conquered. A multifunctional platform based on gold nanoparticles, with multiple receptor targeting, multimodality imaging, and multiple therapeutic entities, holds the promise for a &ldquo;magic gold bullet&rdquo; against cancer.Keywords: gold nanoparticles, cancer, nanotechnology, optical imaging, nanomedicine, molecular therapy Weibo CaiTing GaoHao HongJiangtao SunDove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2008, Iss default, Pp 17-32 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Weibo Cai Ting Gao Hao Hong Jiangtao Sun Applications of gold nanoparticles in cancer nanotechnology
description	Weibo Cai1,2, Ting Gao3, Hao Hong1, Jiangtao Sun11Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin &ndash; Madison, Madison, Wisconsin, USA; 2University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA; 3Tyco Electronics Corporation, 306 Constitution Drive, Menlo Park, California, USAAbstract: It has been almost 4 decades since the &ldquo;war on cancer&rdquo; was declared. It is now generally believed that personalized medicine is the future for cancer patient management. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of cancer, nanoparticles have been extensively studied over the last decade. In this review, we will summarize the current state-of-the-art of gold nanoparticles in biomedical applications targeting cancer. Gold nanospheres, nanorods, nanoshells, nanocages, and surface enhanced Raman scattering nanoparticles will be discussed in detail regarding their uses in in vitro assays, ex vivo and in vivo imaging, cancer therapy, and drug delivery. Multifunctionality is the key feature of nanoparticle-based agents. Targeting ligands, imaging labels, therapeutic drugs, and other functionalities can all be integrated to allow for targeted molecular imaging and molecular therapy of cancer. Big strides have been made and many proof-of-principle studies have been successfully performed. The future looks brighter than ever yet many hurdles remain to be conquered. A multifunctional platform based on gold nanoparticles, with multiple receptor targeting, multimodality imaging, and multiple therapeutic entities, holds the promise for a &ldquo;magic gold bullet&rdquo; against cancer.Keywords: gold nanoparticles, cancer, nanotechnology, optical imaging, nanomedicine, molecular therapy
format	article
author	Weibo Cai Ting Gao Hao Hong Jiangtao Sun
author_facet	Weibo Cai Ting Gao Hao Hong Jiangtao Sun
author_sort	Weibo Cai
title	Applications of gold nanoparticles in cancer nanotechnology
title_short	Applications of gold nanoparticles in cancer nanotechnology
title_full	Applications of gold nanoparticles in cancer nanotechnology
title_fullStr	Applications of gold nanoparticles in cancer nanotechnology
title_full_unstemmed	Applications of gold nanoparticles in cancer nanotechnology
title_sort	applications of gold nanoparticles in cancer nanotechnology
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/4bfbb53a47ce4ec998e992b83b2d0b69
work_keys_str_mv	AT weibocai applicationsofgoldnanoparticlesincancernanotechnology AT tinggao applicationsofgoldnanoparticlesincancernanotechnology AT haohong applicationsofgoldnanoparticlesincancernanotechnology AT jiangtaosun applicationsofgoldnanoparticlesincancernanotechnology
_version_	1718401428714684416

Applications of gold nanoparticles in cancer nanotechnology

Ejemplares similares