Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint

Abstract Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA); mixed results have been reported. We investigated the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA. A tot...

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Autores principales:	Haimuzi Xu, Ji-Hyoun Kang, Sung-Eun Choi, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4bfcd774ecad4ebeb063bb366c1b8f48
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spelling	oai:doaj.org-article:4bfcd774ecad4ebeb063bb366c1b8f482021-12-02T13:50:49ZIncreased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint10.1038/s41598-021-81513-z2045-2322https://doaj.org/article/4bfcd774ecad4ebeb063bb366c1b8f482021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81513-zhttps://doaj.org/toc/2045-2322Abstract Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA); mixed results have been reported. We investigated the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA. A total of 2402 subjects was recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored using a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear and logistic regression analysis. Subjects in the higher serum adiponectin levels tertiles were older and had a lower body mass index (BMI) than those in the lower tertiles. Regarding knee joint scores, serum adiponectin levels was positively associated with the total (P < 0.001), osteophyte (P = 0.003), and joint space narrowing (JSN) scores (P < 0.001) after adjustment for age, sex, BMI, smoking, alcohol consumption, education, and physical activity. In terms of hand joint scores, no association was found between serum adiponectin levels and the total, osteophyte, JSN, subchondral cyst, sclerosis, erosion, or malalignment score after the above-mentioned adjustments. Similarly, subjects with serum adiponectin levels above the median had higher total radiographic scores in the knee joints, but not in the hand joints, after adjustment. An increased serum adiponectin levels was associated with a higher radiographic score in the knee joint, but not in the hand joint, suggesting the involvement of different pathophysiologic mechanisms in the development of OA between those joints.Haimuzi XuJi-Hyoun KangSung-Eun ChoiDong-Jin ParkSun-Seog KweonYoung-Hoon LeeHye-Yeon KimJung-Kil LeeMin-Ho ShinShin-Seok LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haimuzi Xu Ji-Hyoun Kang Sung-Eun Choi Dong-Jin Park Sun-Seog Kweon Young-Hoon Lee Hye-Yeon Kim Jung-Kil Lee Min-Ho Shin Shin-Seok Lee Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
description	Abstract Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA); mixed results have been reported. We investigated the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA. A total of 2402 subjects was recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored using a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear and logistic regression analysis. Subjects in the higher serum adiponectin levels tertiles were older and had a lower body mass index (BMI) than those in the lower tertiles. Regarding knee joint scores, serum adiponectin levels was positively associated with the total (P < 0.001), osteophyte (P = 0.003), and joint space narrowing (JSN) scores (P < 0.001) after adjustment for age, sex, BMI, smoking, alcohol consumption, education, and physical activity. In terms of hand joint scores, no association was found between serum adiponectin levels and the total, osteophyte, JSN, subchondral cyst, sclerosis, erosion, or malalignment score after the above-mentioned adjustments. Similarly, subjects with serum adiponectin levels above the median had higher total radiographic scores in the knee joints, but not in the hand joints, after adjustment. An increased serum adiponectin levels was associated with a higher radiographic score in the knee joint, but not in the hand joint, suggesting the involvement of different pathophysiologic mechanisms in the development of OA between those joints.
format	article
author	Haimuzi Xu Ji-Hyoun Kang Sung-Eun Choi Dong-Jin Park Sun-Seog Kweon Young-Hoon Lee Hye-Yeon Kim Jung-Kil Lee Min-Ho Shin Shin-Seok Lee
author_facet	Haimuzi Xu Ji-Hyoun Kang Sung-Eun Choi Dong-Jin Park Sun-Seog Kweon Young-Hoon Lee Hye-Yeon Kim Jung-Kil Lee Min-Ho Shin Shin-Seok Lee
author_sort	Haimuzi Xu
title	Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
title_short	Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
title_full	Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
title_fullStr	Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
title_full_unstemmed	Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
title_sort	increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4bfcd774ecad4ebeb063bb366c1b8f48
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Increased adiponectin levels are associated with higher radiographic scores in the knee joint, but not in the hand joint

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