PKCɛ switches Aurora B specificity to exit the abscission checkpoint

The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint e...

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Autores principales:	Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4bfd8fc68abe4afca1d2df6a2a1d7ed1
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spelling	oai:doaj.org-article:4bfd8fc68abe4afca1d2df6a2a1d7ed12021-12-02T16:49:58ZPKCɛ switches Aurora B specificity to exit the abscission checkpoint10.1038/ncomms138532041-1723https://doaj.org/article/4bfd8fc68abe4afca1d2df6a2a1d7ed12016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13853https://doaj.org/toc/2041-1723The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint exit.Tanya PikeNicola BrownlowSvend KjaerJeremy CarltonPeter J. ParkerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanya Pike Nicola Brownlow Svend Kjaer Jeremy Carlton Peter J. Parker PKCɛ switches Aurora B specificity to exit the abscission checkpoint
description	The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint exit.
format	article
author	Tanya Pike Nicola Brownlow Svend Kjaer Jeremy Carlton Peter J. Parker
author_facet	Tanya Pike Nicola Brownlow Svend Kjaer Jeremy Carlton Peter J. Parker
author_sort	Tanya Pike
title	PKCɛ switches Aurora B specificity to exit the abscission checkpoint
title_short	PKCɛ switches Aurora B specificity to exit the abscission checkpoint
title_full	PKCɛ switches Aurora B specificity to exit the abscission checkpoint
title_fullStr	PKCɛ switches Aurora B specificity to exit the abscission checkpoint
title_full_unstemmed	PKCɛ switches Aurora B specificity to exit the abscission checkpoint
title_sort	pkcɛ switches aurora b specificity to exit the abscission checkpoint
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4bfd8fc68abe4afca1d2df6a2a1d7ed1
work_keys_str_mv	AT tanyapike pkcɛswitchesaurorabspecificitytoexittheabscissioncheckpoint AT nicolabrownlow pkcɛswitchesaurorabspecificitytoexittheabscissioncheckpoint AT svendkjaer pkcɛswitchesaurorabspecificitytoexittheabscissioncheckpoint AT jeremycarlton pkcɛswitchesaurorabspecificitytoexittheabscissioncheckpoint AT peterjparker pkcɛswitchesaurorabspecificitytoexittheabscissioncheckpoint
_version_	1718383155997573120

PKCɛ switches Aurora B specificity to exit the abscission checkpoint

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