PKCɛ switches Aurora B specificity to exit the abscission checkpoint

The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit Borealin phosphorylation and abscission checkpoint e...

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Autores principales: Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4bfd8fc68abe4afca1d2df6a2a1d7ed1
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