Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration

Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates...

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Autores principales:	Nathan D. Jones, Miguel A. Lopez Jr, Jeungphill Hanne, Mitchell B. Peake, Jong-Bong Lee, Richard Fishel, Kristine E. Yoder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c0178fb357c4b6c9e3c7ff0e81765af
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spelling	oai:doaj.org-article:4c0178fb357c4b6c9e3c7ff0e81765af2021-12-02T15:33:48ZRetroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration10.1038/ncomms114092041-1723https://doaj.org/article/4c0178fb357c4b6c9e3c7ff0e81765af2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11409https://doaj.org/toc/2041-1723Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates.Nathan D. JonesMiguel A. Lopez JrJeungphill HanneMitchell B. PeakeJong-Bong LeeRichard FishelKristine E. YoderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan D. Jones Miguel A. Lopez Jr Jeungphill Hanne Mitchell B. Peake Jong-Bong Lee Richard Fishel Kristine E. Yoder Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
description	Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates.
format	article
author	Nathan D. Jones Miguel A. Lopez Jr Jeungphill Hanne Mitchell B. Peake Jong-Bong Lee Richard Fishel Kristine E. Yoder
author_facet	Nathan D. Jones Miguel A. Lopez Jr Jeungphill Hanne Mitchell B. Peake Jong-Bong Lee Richard Fishel Kristine E. Yoder
author_sort	Nathan D. Jones
title	Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
title_short	Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
title_full	Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
title_fullStr	Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
title_full_unstemmed	Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
title_sort	retroviral intasomes search for a target dna by 1d diffusion which rarely results in integration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4c0178fb357c4b6c9e3c7ff0e81765af
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Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration

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