Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration

Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates...

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Autores principales: Nathan D. Jones, Miguel A. Lopez Jr, Jeungphill Hanne, Mitchell B. Peake, Jong-Bong Lee, Richard Fishel, Kristine E. Yoder
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4c0178fb357c4b6c9e3c7ff0e81765af
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