Multiple Mutations in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> MmpL3 Increase Resistance to MmpL3 Inhibitors
ABSTRACT The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane. Numerous structurally diverse pharmacophores have been identified as inhibitors of MmpL3 largely based on the...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4c02b40a4efc4a7ba9a7328330adaff6 |
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