MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.

<h4>Background</h4>The brain is a major site of microRNA (miRNA) gene expression, but the spatial expression patterns of miRNAs within the brain have not yet been fully covered.<h4>Methodology/principal findings</h4>We have characterized the regional expression profiles of mi...

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Autores principales:	Line Olsen, Mikkel Klausen, Lone Helboe, Finn Cilius Nielsen, Thomas Werge
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c067c2f96b44849888e3224c985bd32
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spelling	oai:doaj.org-article:4c067c2f96b44849888e3224c985bd322021-11-25T06:19:53ZMicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.1932-620310.1371/journal.pone.0007225https://doaj.org/article/4c067c2f96b44849888e3224c985bd322009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19806225/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The brain is a major site of microRNA (miRNA) gene expression, but the spatial expression patterns of miRNAs within the brain have not yet been fully covered.<h4>Methodology/principal findings</h4>We have characterized the regional expression profiles of miRNAs in five distinct regions of the adult rat brain: amygdala, cerebellum, hippocampus, hypothalamus and substantia nigra. Microarray profiling uncovered 48 miRNAs displaying more than three-fold enrichment between two or more brain regions. Notably, we found reciprocal expression profiles for a subset of the miRNAs predominantly found (> ten times) in either the cerebellum (miR-206 and miR-497) or the forebrain regions (miR-132, miR-212, miR-221 and miR-222).<h4>Conclusions/significance</h4>The results indicate that some miRNAs could be important for area-specific functions in the brain. Our data, combined with previous studies in mice, provides additional guidance for future investigations of miRNA functions in the brain.Line OlsenMikkel KlausenLone HelboeFinn Cilius NielsenThomas WergePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 10, p e7225 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Line Olsen Mikkel Klausen Lone Helboe Finn Cilius Nielsen Thomas Werge MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
description	<h4>Background</h4>The brain is a major site of microRNA (miRNA) gene expression, but the spatial expression patterns of miRNAs within the brain have not yet been fully covered.<h4>Methodology/principal findings</h4>We have characterized the regional expression profiles of miRNAs in five distinct regions of the adult rat brain: amygdala, cerebellum, hippocampus, hypothalamus and substantia nigra. Microarray profiling uncovered 48 miRNAs displaying more than three-fold enrichment between two or more brain regions. Notably, we found reciprocal expression profiles for a subset of the miRNAs predominantly found (> ten times) in either the cerebellum (miR-206 and miR-497) or the forebrain regions (miR-132, miR-212, miR-221 and miR-222).<h4>Conclusions/significance</h4>The results indicate that some miRNAs could be important for area-specific functions in the brain. Our data, combined with previous studies in mice, provides additional guidance for future investigations of miRNA functions in the brain.
format	article
author	Line Olsen Mikkel Klausen Lone Helboe Finn Cilius Nielsen Thomas Werge
author_facet	Line Olsen Mikkel Klausen Lone Helboe Finn Cilius Nielsen Thomas Werge
author_sort	Line Olsen
title	MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
title_short	MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
title_full	MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
title_fullStr	MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
title_full_unstemmed	MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.
title_sort	micrornas show mutually exclusive expression patterns in the brain of adult male rats.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/4c067c2f96b44849888e3224c985bd32
work_keys_str_mv	AT lineolsen micrornasshowmutuallyexclusiveexpressionpatternsinthebrainofadultmalerats AT mikkelklausen micrornasshowmutuallyexclusiveexpressionpatternsinthebrainofadultmalerats AT lonehelboe micrornasshowmutuallyexclusiveexpressionpatternsinthebrainofadultmalerats AT finnciliusnielsen micrornasshowmutuallyexclusiveexpressionpatternsinthebrainofadultmalerats AT thomaswerge micrornasshowmutuallyexclusiveexpressionpatternsinthebrainofadultmalerats
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MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.

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