Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis

Abstract On the basis of 45,092 participants (mean age of 54.04 ± 13.09 years) from the Kailuan study, this study was performed to explore the relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) and quantify their separate effects...

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Autores principales:	Haojia Chen, Youren Chen, Weiqiang Wu, Zefeng Cai, Zhichao Chen, Xiuzhu Yan, Shouling Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c067ee9b2bc4e5c94d750c8a75cb049
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spelling	oai:doaj.org-article:4c067ee9b2bc4e5c94d750c8a75cb0492021-12-02T14:01:23ZTotal cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis10.1038/s41598-020-79368-x2045-2322https://doaj.org/article/4c067ee9b2bc4e5c94d750c8a75cb0492021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79368-xhttps://doaj.org/toc/2045-2322Abstract On the basis of 45,092 participants (mean age of 54.04 ± 13.09 years) from the Kailuan study, this study was performed to explore the relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) and quantify their separate effects. The correlations among TC, SBP, and BaPWV were analyzed using multivariate linear regression models. Mediation analysis was performed to determine whether the effect of TC on SBP can be explained by arterial stiffness. Multivariate linear regression analysis showed that for every one standard deviation increase in TC and BaPWV, SBP increased by 0.33 mmHg and 0.044 mmHg, respectively; for every one standard deviation increase in TC, BaPWV increased by 5.34 cm/s. Mediation analysis showed that the TC-induced SBP elevation was mediated by arterial stiffness in more than half of the whole cohort (indirect effect, 0.73; percent mediated, 54.5%). Furthermore, the TC-induced SBP elevation was mediated by arterial stiffness in less than half of the males (indirect effect, 0.70; percent mediated, 47.9%); however, the results were not statistically significant in females. In conclusion, TC and BaPWV are positively correlated with SBP, whereas TC is positively correlated with BaPWV. Almost half of the increase in SBP contributed to TC is mediated by arterial stiffness.Haojia ChenYouren ChenWeiqiang WuZefeng CaiZhichao ChenXiuzhu YanShouling WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haojia Chen Youren Chen Weiqiang Wu Zefeng Cai Zhichao Chen Xiuzhu Yan Shouling Wu Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
description	Abstract On the basis of 45,092 participants (mean age of 54.04 ± 13.09 years) from the Kailuan study, this study was performed to explore the relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) and quantify their separate effects. The correlations among TC, SBP, and BaPWV were analyzed using multivariate linear regression models. Mediation analysis was performed to determine whether the effect of TC on SBP can be explained by arterial stiffness. Multivariate linear regression analysis showed that for every one standard deviation increase in TC and BaPWV, SBP increased by 0.33 mmHg and 0.044 mmHg, respectively; for every one standard deviation increase in TC, BaPWV increased by 5.34 cm/s. Mediation analysis showed that the TC-induced SBP elevation was mediated by arterial stiffness in more than half of the whole cohort (indirect effect, 0.73; percent mediated, 54.5%). Furthermore, the TC-induced SBP elevation was mediated by arterial stiffness in less than half of the males (indirect effect, 0.70; percent mediated, 47.9%); however, the results were not statistically significant in females. In conclusion, TC and BaPWV are positively correlated with SBP, whereas TC is positively correlated with BaPWV. Almost half of the increase in SBP contributed to TC is mediated by arterial stiffness.
format	article
author	Haojia Chen Youren Chen Weiqiang Wu Zefeng Cai Zhichao Chen Xiuzhu Yan Shouling Wu
author_facet	Haojia Chen Youren Chen Weiqiang Wu Zefeng Cai Zhichao Chen Xiuzhu Yan Shouling Wu
author_sort	Haojia Chen
title	Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
title_short	Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
title_full	Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
title_fullStr	Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
title_full_unstemmed	Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
title_sort	total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c067ee9b2bc4e5c94d750c8a75cb049
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Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis

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