Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Hassan Khojasteh,1 Rasoul Amini Vishte,2 Ali Mirzajani,2 Elias Khalili Pour,1 Fatemeh Bazvand,1 Hamid Riazi-Esfahani,1 Masoud Mirghorbani,1 Bobeck S Modjtahedi3– 5 1Department of Ophthalmology, Farabi Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran,...

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Autores principales:	Khojasteh H, Amini Vishte R, Mirzajani A, Khalili Pour E, Bazvand F, Riazi-Esfahani H, Mirghorbani M, Modjtahedi BS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic retinopathy electroretinogram pan-retinal photocoagulation laser Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4c075e486cad47c4bbd6d8c38a7ddcb3
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spelling	oai:doaj.org-article:4c075e486cad47c4bbd6d8c38a7ddcb32021-12-02T09:08:29ZElectroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy1177-5483https://doaj.org/article/4c075e486cad47c4bbd6d8c38a7ddcb32020-03-01T00:00:00Zhttps://www.dovepress.com/electroretinogram-changes-following-sequential-panretinal-photocoagula-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hassan Khojasteh,1 Rasoul Amini Vishte,2 Ali Mirzajani,2 Elias Khalili Pour,1 Fatemeh Bazvand,1 Hamid Riazi-Esfahani,1 Masoud Mirghorbani,1 Bobeck S Modjtahedi3– 5 1Department of Ophthalmology, Farabi Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran; 3Department of Ophthalmology, Southern California Permanente Medical Group, Baldwin Park, CA, USA; 4Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, USA; 5Eye Monitoring Center, Kaiser Permanente Southern California, Baldwin Park, CA, USACorrespondence: Hassan Khojasteh Email khojaste_hasan@yahoo.comPurpose: To evaluate changes in electroretinogram (ERG) response over the course of multiple sessions of panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PRP).Methods: A prospective cohort study of 11 patients with PDR who required PRP was conducted. PRP was completed over three sessions. Each patient had five ERGs done: baseline, 1 week after each PRP session, and 6 weeks after the last session of PRP. Dark-adapted 0.01 ERG, Dark-adapted 3 ERG, Dark-adapted 10 ERG, Light- adapted 3 ERG, and Light-adapted 30 Hz flicker ERG were done. The mean change in a- and b-wave amplitudes as well as implicit times compared to baseline was analyzed.Results: A significant reduction in peak amplitudes of both a- and b-waves and delay in latencies were observed in all responses (p< 0.05). The absolute amplitude reduction and delay in latency were higher for scotopic b-waves (p< 0.05). The root mean square (RMS) of Dark-adapted 10.0 ERG (p< 0.05) and total mean amplitude changes of a- and b-waves (p< 0.001) were reduced after each laser session; however, the magnitude of change was not different between the first, second, or third sessions of PRP, and each session showed a similar deterioration rate of ERG parameters comparing to each other (p=0.4 for RMS and p=0.2 for total mean amplitude changes). In addition, the results indicated recovery of the amplitude and latency of ERG waves after 6 weeks from the final treatment (p< 0.001) although not to baseline levels.Conclusion: ERG findings following PRP show reduced retinal function after each session which partially recovers by 6 weeks after the completion of therapy. Clinicians should be mindful of these changes when planning the treatment course for patients with PDR.Keywords: diabetic retinopathy, electroretinogram, panretinal photocoagulation, laserKhojasteh HAmini Vishte RMirzajani AKhalili Pour EBazvand FRiazi-Esfahani HMirghorbani MModjtahedi BSDove Medical Pressarticlediabetic retinopathyelectroretinogrampan-retinal photocoagulationlaserOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 967-975 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy electroretinogram pan-retinal photocoagulation laser Ophthalmology RE1-994
spellingShingle	diabetic retinopathy electroretinogram pan-retinal photocoagulation laser Ophthalmology RE1-994 Khojasteh H Amini Vishte R Mirzajani A Khalili Pour E Bazvand F Riazi-Esfahani H Mirghorbani M Modjtahedi BS Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
description	Hassan Khojasteh,1 Rasoul Amini Vishte,2 Ali Mirzajani,2 Elias Khalili Pour,1 Fatemeh Bazvand,1 Hamid Riazi-Esfahani,1 Masoud Mirghorbani,1 Bobeck S Modjtahedi3– 5 1Department of Ophthalmology, Farabi Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran; 3Department of Ophthalmology, Southern California Permanente Medical Group, Baldwin Park, CA, USA; 4Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, USA; 5Eye Monitoring Center, Kaiser Permanente Southern California, Baldwin Park, CA, USACorrespondence: Hassan Khojasteh Email khojaste_hasan@yahoo.comPurpose: To evaluate changes in electroretinogram (ERG) response over the course of multiple sessions of panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PRP).Methods: A prospective cohort study of 11 patients with PDR who required PRP was conducted. PRP was completed over three sessions. Each patient had five ERGs done: baseline, 1 week after each PRP session, and 6 weeks after the last session of PRP. Dark-adapted 0.01 ERG, Dark-adapted 3 ERG, Dark-adapted 10 ERG, Light- adapted 3 ERG, and Light-adapted 30 Hz flicker ERG were done. The mean change in a- and b-wave amplitudes as well as implicit times compared to baseline was analyzed.Results: A significant reduction in peak amplitudes of both a- and b-waves and delay in latencies were observed in all responses (p< 0.05). The absolute amplitude reduction and delay in latency were higher for scotopic b-waves (p< 0.05). The root mean square (RMS) of Dark-adapted 10.0 ERG (p< 0.05) and total mean amplitude changes of a- and b-waves (p< 0.001) were reduced after each laser session; however, the magnitude of change was not different between the first, second, or third sessions of PRP, and each session showed a similar deterioration rate of ERG parameters comparing to each other (p=0.4 for RMS and p=0.2 for total mean amplitude changes). In addition, the results indicated recovery of the amplitude and latency of ERG waves after 6 weeks from the final treatment (p< 0.001) although not to baseline levels.Conclusion: ERG findings following PRP show reduced retinal function after each session which partially recovers by 6 weeks after the completion of therapy. Clinicians should be mindful of these changes when planning the treatment course for patients with PDR.Keywords: diabetic retinopathy, electroretinogram, panretinal photocoagulation, laser
format	article
author	Khojasteh H Amini Vishte R Mirzajani A Khalili Pour E Bazvand F Riazi-Esfahani H Mirghorbani M Modjtahedi BS
author_facet	Khojasteh H Amini Vishte R Mirzajani A Khalili Pour E Bazvand F Riazi-Esfahani H Mirghorbani M Modjtahedi BS
author_sort	Khojasteh H
title	Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
title_short	Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
title_full	Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
title_fullStr	Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
title_full_unstemmed	Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
title_sort	electroretinogram changes following sequential panretinal photocoagulation for proliferative diabetic retinopathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4c075e486cad47c4bbd6d8c38a7ddcb3
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Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

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