Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive...

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Autores principales:	Yoshitaka Kimura, Daisuke Tsukui, Hajime Kono
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyperuricemia atherosclerosis inflammation reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4c0b5fcc8f7046d79c0b7b979afcfc51
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spelling	oai:doaj.org-article:4c0b5fcc8f7046d79c0b7b979afcfc512021-11-25T17:56:18ZUric Acid in Inflammation and the Pathogenesis of Atherosclerosis10.3390/ijms2222123941422-00671661-6596https://doaj.org/article/4c0b5fcc8f7046d79c0b7b979afcfc512021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12394https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.Yoshitaka KimuraDaisuke TsukuiHajime KonoMDPI AGarticlehyperuricemiaatherosclerosisinflammationreactive oxygen speciesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12394, p 12394 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperuricemia atherosclerosis inflammation reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	hyperuricemia atherosclerosis inflammation reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999 Yoshitaka Kimura Daisuke Tsukui Hajime Kono Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
description	Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.
format	article
author	Yoshitaka Kimura Daisuke Tsukui Hajime Kono
author_facet	Yoshitaka Kimura Daisuke Tsukui Hajime Kono
author_sort	Yoshitaka Kimura
title	Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
title_short	Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
title_full	Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
title_fullStr	Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
title_full_unstemmed	Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
title_sort	uric acid in inflammation and the pathogenesis of atherosclerosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4c0b5fcc8f7046d79c0b7b979afcfc51
work_keys_str_mv	AT yoshitakakimura uricacidininflammationandthepathogenesisofatherosclerosis AT daisuketsukui uricacidininflammationandthepathogenesisofatherosclerosis AT hajimekono uricacidininflammationandthepathogenesisofatherosclerosis
_version_	1718411800924389376

Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis

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