Oral microflora and pregnancy: a systematic review and meta-analysis

Abstract Understanding changes in oral flora during pregnancy, its association to maternal health, and its implications to birth outcomes is essential. We searched PubMed, Embase, Web of Science, and Cochrane Library in May 2020 (updated search in April and June 2021), and conducted a systematic rev...

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Autores principales:	Hoonji Jang, Alexa Patoine, Tong Tong Wu, Daniel A. Castillo, Jin Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c0f520ae76742068228c82c26c76ee1
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spelling	oai:doaj.org-article:4c0f520ae76742068228c82c26c76ee12021-12-02T15:10:34ZOral microflora and pregnancy: a systematic review and meta-analysis10.1038/s41598-021-96495-12045-2322https://doaj.org/article/4c0f520ae76742068228c82c26c76ee12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96495-1https://doaj.org/toc/2045-2322Abstract Understanding changes in oral flora during pregnancy, its association to maternal health, and its implications to birth outcomes is essential. We searched PubMed, Embase, Web of Science, and Cochrane Library in May 2020 (updated search in April and June 2021), and conducted a systematic review and meta-analyses to assess the followings: (1) oral microflora changes throughout pregnancy, (2) association between oral microorganisms during pregnancy and maternal oral/systemic conditions, and (3) implications of oral microorganisms during pregnancy on birth outcomes. From 3983 records, 78 studies were included for qualitative assessment, and 13 studies were included in meta-analysis. The oral microflora remains relatively stable during pregnancy; however, pregnancy was associated with distinct composition/abundance of oral microorganisms when compared to postpartum/non-pregnant status. Oral microflora during pregnancy appears to be influenced by oral and systemic conditions (e.g. gestational diabetes mellitus, pre-eclampsia, etc.). Prenatal dental care reduced the carriage of oral pathogens (e.g. Streptococcus mutans). The Porphyromonas gingivalis in subgingival plaque was more abundant in women with preterm birth. Given the results from meta-analyses were inconclusive since limited studies reported outcomes on the same measuring scale, more future studies are needed to elucidate the association between pregnancy oral microbiota and maternal oral/systemic health and birth outcomes.Hoonji JangAlexa PatoineTong Tong WuDaniel A. CastilloJin XiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hoonji Jang Alexa Patoine Tong Tong Wu Daniel A. Castillo Jin Xiao Oral microflora and pregnancy: a systematic review and meta-analysis
description	Abstract Understanding changes in oral flora during pregnancy, its association to maternal health, and its implications to birth outcomes is essential. We searched PubMed, Embase, Web of Science, and Cochrane Library in May 2020 (updated search in April and June 2021), and conducted a systematic review and meta-analyses to assess the followings: (1) oral microflora changes throughout pregnancy, (2) association between oral microorganisms during pregnancy and maternal oral/systemic conditions, and (3) implications of oral microorganisms during pregnancy on birth outcomes. From 3983 records, 78 studies were included for qualitative assessment, and 13 studies were included in meta-analysis. The oral microflora remains relatively stable during pregnancy; however, pregnancy was associated with distinct composition/abundance of oral microorganisms when compared to postpartum/non-pregnant status. Oral microflora during pregnancy appears to be influenced by oral and systemic conditions (e.g. gestational diabetes mellitus, pre-eclampsia, etc.). Prenatal dental care reduced the carriage of oral pathogens (e.g. Streptococcus mutans). The Porphyromonas gingivalis in subgingival plaque was more abundant in women with preterm birth. Given the results from meta-analyses were inconclusive since limited studies reported outcomes on the same measuring scale, more future studies are needed to elucidate the association between pregnancy oral microbiota and maternal oral/systemic health and birth outcomes.
format	article
author	Hoonji Jang Alexa Patoine Tong Tong Wu Daniel A. Castillo Jin Xiao
author_facet	Hoonji Jang Alexa Patoine Tong Tong Wu Daniel A. Castillo Jin Xiao
author_sort	Hoonji Jang
title	Oral microflora and pregnancy: a systematic review and meta-analysis
title_short	Oral microflora and pregnancy: a systematic review and meta-analysis
title_full	Oral microflora and pregnancy: a systematic review and meta-analysis
title_fullStr	Oral microflora and pregnancy: a systematic review and meta-analysis
title_full_unstemmed	Oral microflora and pregnancy: a systematic review and meta-analysis
title_sort	oral microflora and pregnancy: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c0f520ae76742068228c82c26c76ee1
work_keys_str_mv	AT hoonjijang oralmicrofloraandpregnancyasystematicreviewandmetaanalysis AT alexapatoine oralmicrofloraandpregnancyasystematicreviewandmetaanalysis AT tongtongwu oralmicrofloraandpregnancyasystematicreviewandmetaanalysis AT danielacastillo oralmicrofloraandpregnancyasystematicreviewandmetaanalysis AT jinxiao oralmicrofloraandpregnancyasystematicreviewandmetaanalysis
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Oral microflora and pregnancy: a systematic review and meta-analysis

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