HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.

HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.

In B-Chronic Lymphocytic Leukemia (B-CLL) kinase Lyn is overexpressed, active, abnormally distributed, and part of a cytosolic complex involving hematopoietic lineage cell-specific protein 1 (HS1). These aberrant properties of Lyn could partially explain leukemic cells' defective apoptosis, dir...

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Autores principales: Federica Frezzato, Cristina Gattazzo, Veronica Martini, Valentina Trimarco, Antonella Teramo, Samuela Carraro, Anna Cabrelle, Elisa Ave, Monica Facco, Renato Zambello, Elena Tibaldi, Anna Maria Brunati, Gianpietro Semenzato, Livio Trentin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/4c11441ec61446e6a96d7f2b910105d5
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