Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

<h4>Background</h4>The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investiga...

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Autores principales: Pathricia V Tilstam, Marion J Gijbels, Mohamed Habbeddine, Céline Cudejko, Yaw Asare, Wendy Theelen, Baixue Zhou, Yvonne Döring, Maik Drechsler, Lukas Pawig, Sakine Simsekyilmaz, Rory R Koenen, Menno P J de Winther, Toby Lawrence, Jürgen Bernhagen, Alma Zernecke, Christian Weber, Heidi Noels
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4c1509550b444460abf7231c1a2b2fe3
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