Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling
The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubling and aneuploidy.
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Nature Portfolio
2021
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oai:doaj.org-article:4c17fb9d0e02463397deea2b50e28d352021-12-02T13:33:04ZEvolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling10.1038/s41467-021-21576-82041-1723https://doaj.org/article/4c17fb9d0e02463397deea2b50e28d352021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21576-8https://doaj.org/toc/2041-1723The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubling and aneuploidy.Ismael A. VergaraChristopher P. MintoffShahneen SandhuLachlan McIntoshRichard J. YoungStephen Q. WongAndrew ColebatchDaniel L. CameronJulia Lai KwonRory WolfeAngela PengJason EllulXuelin DouClare FedeleSamantha BoyleGisela Mir ArnauJeanette RaleighAthena HatzimihalisPacman SzetoJennifer MooiDaniel S. WidmerPhil F. ChengValerie AmannReinhard DummerNicholas HaywardJames WilmottRichard A. ScolyerRaymond J. ChoDavid BowtellHeather ThorneKathryn AlsopStephen CordnerNoel WoodfordJodie LeditschkePatricia O’BrienSarah-Jane DawsonGrant A. McArthurGraham J. MannMitchell P. LevesqueAnthony T. PapenfussMark ShackletonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Ismael A. Vergara Christopher P. Mintoff Shahneen Sandhu Lachlan McIntosh Richard J. Young Stephen Q. Wong Andrew Colebatch Daniel L. Cameron Julia Lai Kwon Rory Wolfe Angela Peng Jason Ellul Xuelin Dou Clare Fedele Samantha Boyle Gisela Mir Arnau Jeanette Raleigh Athena Hatzimihalis Pacman Szeto Jennifer Mooi Daniel S. Widmer Phil F. Cheng Valerie Amann Reinhard Dummer Nicholas Hayward James Wilmott Richard A. Scolyer Raymond J. Cho David Bowtell Heather Thorne Kathryn Alsop Stephen Cordner Noel Woodford Jodie Leditschke Patricia O’Brien Sarah-Jane Dawson Grant A. McArthur Graham J. Mann Mitchell P. Levesque Anthony T. Papenfuss Mark Shackleton Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| description |
The genetic changes that occur in late stage metastatic melanoma are not well delineated. Here, the authors use rapid autopsy samples from metastatic melanoma patients and show that the late stage in the disease is characterised by whole genome doubling and aneuploidy. |
| format |
article |
| author |
Ismael A. Vergara Christopher P. Mintoff Shahneen Sandhu Lachlan McIntosh Richard J. Young Stephen Q. Wong Andrew Colebatch Daniel L. Cameron Julia Lai Kwon Rory Wolfe Angela Peng Jason Ellul Xuelin Dou Clare Fedele Samantha Boyle Gisela Mir Arnau Jeanette Raleigh Athena Hatzimihalis Pacman Szeto Jennifer Mooi Daniel S. Widmer Phil F. Cheng Valerie Amann Reinhard Dummer Nicholas Hayward James Wilmott Richard A. Scolyer Raymond J. Cho David Bowtell Heather Thorne Kathryn Alsop Stephen Cordner Noel Woodford Jodie Leditschke Patricia O’Brien Sarah-Jane Dawson Grant A. McArthur Graham J. Mann Mitchell P. Levesque Anthony T. Papenfuss Mark Shackleton |
| author_facet |
Ismael A. Vergara Christopher P. Mintoff Shahneen Sandhu Lachlan McIntosh Richard J. Young Stephen Q. Wong Andrew Colebatch Daniel L. Cameron Julia Lai Kwon Rory Wolfe Angela Peng Jason Ellul Xuelin Dou Clare Fedele Samantha Boyle Gisela Mir Arnau Jeanette Raleigh Athena Hatzimihalis Pacman Szeto Jennifer Mooi Daniel S. Widmer Phil F. Cheng Valerie Amann Reinhard Dummer Nicholas Hayward James Wilmott Richard A. Scolyer Raymond J. Cho David Bowtell Heather Thorne Kathryn Alsop Stephen Cordner Noel Woodford Jodie Leditschke Patricia O’Brien Sarah-Jane Dawson Grant A. McArthur Graham J. Mann Mitchell P. Levesque Anthony T. Papenfuss Mark Shackleton |
| author_sort |
Ismael A. Vergara |
| title |
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| title_short |
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| title_full |
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| title_fullStr |
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| title_full_unstemmed |
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| title_sort |
evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4c17fb9d0e02463397deea2b50e28d35 |
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