Divergent mutational processes distinguish hypoxic and normoxic tumours

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

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Autores principales:	Vinayak Bhandari, Constance H. Li, Robert G. Bristow, Paul C. Boutros, PCAWG Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c1bcf031d81481c82255bf73212374c
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spelling	oai:doaj.org-article:4c1bcf031d81481c82255bf73212374c2021-12-02T17:31:40ZDivergent mutational processes distinguish hypoxic and normoxic tumours10.1038/s41467-019-14052-x2041-1723https://doaj.org/article/4c1bcf031d81481c82255bf73212374c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14052-xhttps://doaj.org/toc/2041-1723Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.Vinayak BhandariConstance H. LiRobert G. BristowPaul C. BoutrosPCAWG ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vinayak Bhandari Constance H. Li Robert G. Bristow Paul C. Boutros PCAWG Consortium Divergent mutational processes distinguish hypoxic and normoxic tumours
description	Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.
format	article
author	Vinayak Bhandari Constance H. Li Robert G. Bristow Paul C. Boutros PCAWG Consortium
author_facet	Vinayak Bhandari Constance H. Li Robert G. Bristow Paul C. Boutros PCAWG Consortium
author_sort	Vinayak Bhandari
title	Divergent mutational processes distinguish hypoxic and normoxic tumours
title_short	Divergent mutational processes distinguish hypoxic and normoxic tumours
title_full	Divergent mutational processes distinguish hypoxic and normoxic tumours
title_fullStr	Divergent mutational processes distinguish hypoxic and normoxic tumours
title_full_unstemmed	Divergent mutational processes distinguish hypoxic and normoxic tumours
title_sort	divergent mutational processes distinguish hypoxic and normoxic tumours
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c1bcf031d81481c82255bf73212374c
work_keys_str_mv	AT vinayakbhandari divergentmutationalprocessesdistinguishhypoxicandnormoxictumours AT constancehli divergentmutationalprocessesdistinguishhypoxicandnormoxictumours AT robertgbristow divergentmutationalprocessesdistinguishhypoxicandnormoxictumours AT paulcboutros divergentmutationalprocessesdistinguishhypoxicandnormoxictumours AT pcawgconsortium divergentmutationalprocessesdistinguishhypoxicandnormoxictumours
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Divergent mutational processes distinguish hypoxic and normoxic tumours

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