Divergent mutational processes distinguish hypoxic and normoxic tumours

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

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Detalles Bibliográficos
Autores principales: Vinayak Bhandari, Constance H. Li, Robert G. Bristow, Paul C. Boutros, PCAWG Consortium
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4c1bcf031d81481c82255bf73212374c
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