Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination

Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS). Remyelination is the natural regenerating process after demyelination that also provides neuroprotection but is often incomplete or fails i...

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Autores principales:	Viktoria Gudi, Nora Schäfer, Stefan Gingele, Martin Stangel, Thomas Skripuletz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple sclerosis CDP-choline cuprizone microglia astrocytes oligodendrocytes Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4c1c590b6af54b23a2625ad0b0e2d666
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spelling	oai:doaj.org-article:4c1c590b6af54b23a2625ad0b0e2d6662021-11-25T18:39:46ZRegenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination10.3390/ph141111561424-8247https://doaj.org/article/4c1c590b6af54b23a2625ad0b0e2d6662021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1156https://doaj.org/toc/1424-8247Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS). Remyelination is the natural regenerating process after demyelination that also provides neuroprotection but is often incomplete or fails in MS. Currently available therapeutics are affecting the immune system, but there is no substance that might enhance remyelination. Cytidine-S-diphosphate choline (CDP-choline), a precursor of the biomembrane component phospholipid phosphatidylcholine was shown to improve remyelination in two animal models of demyelination. However, the doses used in previous animal studies were high (500 mg/kg), and it is not clear if lower doses, which could be applied in human trials, might exert the same beneficial effect on remyelination. The aim of this study was to confirm previous results and to determine the potential regenerative effects of lower doses of CDP-choline (100 and 50 mg/kg). The effects of CDP-choline were investigated in the toxic cuprizone-induced mouse model of de- and remyelination. We found that even low doses of CDP-choline effectively enhanced early remyelination. The beneficial effects on myelin regeneration were accompanied by higher numbers of oligodendrocytes. In conclusion, CDP-choline could become a promising regenerative substance for patients with multiple sclerosis and should be tested in a clinical trial.Viktoria GudiNora SchäferStefan GingeleMartin StangelThomas SkripuletzMDPI AGarticlemultiple sclerosisCDP-cholinecuprizonemicrogliaastrocytesoligodendrocytesMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1156, p 1156 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis CDP-choline cuprizone microglia astrocytes oligodendrocytes Medicine R Pharmacy and materia medica RS1-441
spellingShingle	multiple sclerosis CDP-choline cuprizone microglia astrocytes oligodendrocytes Medicine R Pharmacy and materia medica RS1-441 Viktoria Gudi Nora Schäfer Stefan Gingele Martin Stangel Thomas Skripuletz Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
description	Inflammatory attacks and demyelination in the central nervous system (CNS) are the key factors responsible for the damage of neurons in multiple sclerosis (MS). Remyelination is the natural regenerating process after demyelination that also provides neuroprotection but is often incomplete or fails in MS. Currently available therapeutics are affecting the immune system, but there is no substance that might enhance remyelination. Cytidine-S-diphosphate choline (CDP-choline), a precursor of the biomembrane component phospholipid phosphatidylcholine was shown to improve remyelination in two animal models of demyelination. However, the doses used in previous animal studies were high (500 mg/kg), and it is not clear if lower doses, which could be applied in human trials, might exert the same beneficial effect on remyelination. The aim of this study was to confirm previous results and to determine the potential regenerative effects of lower doses of CDP-choline (100 and 50 mg/kg). The effects of CDP-choline were investigated in the toxic cuprizone-induced mouse model of de- and remyelination. We found that even low doses of CDP-choline effectively enhanced early remyelination. The beneficial effects on myelin regeneration were accompanied by higher numbers of oligodendrocytes. In conclusion, CDP-choline could become a promising regenerative substance for patients with multiple sclerosis and should be tested in a clinical trial.
format	article
author	Viktoria Gudi Nora Schäfer Stefan Gingele Martin Stangel Thomas Skripuletz
author_facet	Viktoria Gudi Nora Schäfer Stefan Gingele Martin Stangel Thomas Skripuletz
author_sort	Viktoria Gudi
title	Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
title_short	Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
title_full	Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
title_fullStr	Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
title_full_unstemmed	Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
title_sort	regenerative effects of cdp-choline: a dose-dependent study in the toxic cuprizone model of de- and remyelination
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4c1c590b6af54b23a2625ad0b0e2d666
work_keys_str_mv	AT viktoriagudi regenerativeeffectsofcdpcholineadosedependentstudyinthetoxiccuprizonemodelofdeandremyelination AT noraschafer regenerativeeffectsofcdpcholineadosedependentstudyinthetoxiccuprizonemodelofdeandremyelination AT stefangingele regenerativeeffectsofcdpcholineadosedependentstudyinthetoxiccuprizonemodelofdeandremyelination AT martinstangel regenerativeeffectsofcdpcholineadosedependentstudyinthetoxiccuprizonemodelofdeandremyelination AT thomasskripuletz regenerativeeffectsofcdpcholineadosedependentstudyinthetoxiccuprizonemodelofdeandremyelination
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Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination

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