A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease

Abstract Parkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-depende...

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Autores principales:	Emahnuel Troisi Lopez, Roberta Minino, Pierpaolo Sorrentino, Rosaria Rucco, Anna Carotenuto, Valeria Agosti, Domenico Tafuri, Valentino Manzo, Marianna Liparoti, Giuseppe Sorrentino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c1ee849e2594ab6b0e1c2ac3a932195
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spelling	oai:doaj.org-article:4c1ee849e2594ab6b0e1c2ac3a9321952021-12-02T14:06:11ZA synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease10.1038/s41598-021-82348-42045-2322https://doaj.org/article/4c1ee849e2594ab6b0e1c2ac3a9321952021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82348-4https://doaj.org/toc/2045-2322Abstract Parkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. Hence, we have designed a new measure of postural stability which assesses the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI). Twenty-three PD patients and twenty-three healthy controls underwent motor examination through a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with gait parameters and clinical motor scale (UPDRS-III). The TDI sensitivity was estimated, comparing pre- and post- L-DOPA subclinical dose intake. The TDI showed significant correlations with many gait parameters and with the UPDRS-III. Furthermore, the TDI resulted capable in discriminating between off and on state in PD, whereas gait parameters failed two show any difference between those two conditions. Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.Emahnuel Troisi LopezRoberta MininoPierpaolo SorrentinoRosaria RuccoAnna CarotenutoValeria AgostiDomenico TafuriValentino ManzoMarianna LiparotiGiuseppe SorrentinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emahnuel Troisi Lopez Roberta Minino Pierpaolo Sorrentino Rosaria Rucco Anna Carotenuto Valeria Agosti Domenico Tafuri Valentino Manzo Marianna Liparoti Giuseppe Sorrentino A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
description	Abstract Parkinson's disease (PD) is characterized by motor impairment, affecting quality of life and increasing fall risk, due to ineffective postural control. To this day, the diagnosis remains based on clinical approach. Similarly, motor evaluation is based on heterogeneous, operator-dependent observational criteria. A synthetic, replicable index to quantify motor impairment is still lacking. Hence, we have designed a new measure of postural stability which assesses the trunk displacement in relation to the center of mass, that we named trunk displacement index (TDI). Twenty-three PD patients and twenty-three healthy controls underwent motor examination through a stereophotogrammetric system. A correlation analysis was performed to assess the relationship of TDI with gait parameters and clinical motor scale (UPDRS-III). The TDI sensitivity was estimated, comparing pre- and post- L-DOPA subclinical dose intake. The TDI showed significant correlations with many gait parameters and with the UPDRS-III. Furthermore, the TDI resulted capable in discriminating between off and on state in PD, whereas gait parameters failed two show any difference between those two conditions. Our results suggest that the TDI may be considered a highly sensitive biomechanical index, reflecting the overall motor condition in PD, and provided of clinical relevance due to the correlation with the clinical evaluation.
format	article
author	Emahnuel Troisi Lopez Roberta Minino Pierpaolo Sorrentino Rosaria Rucco Anna Carotenuto Valeria Agosti Domenico Tafuri Valentino Manzo Marianna Liparoti Giuseppe Sorrentino
author_facet	Emahnuel Troisi Lopez Roberta Minino Pierpaolo Sorrentino Rosaria Rucco Anna Carotenuto Valeria Agosti Domenico Tafuri Valentino Manzo Marianna Liparoti Giuseppe Sorrentino
author_sort	Emahnuel Troisi Lopez
title	A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
title_short	A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
title_full	A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
title_fullStr	A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
title_full_unstemmed	A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease
title_sort	synthetic kinematic index of trunk displacement conveying the overall motor condition in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c1ee849e2594ab6b0e1c2ac3a932195
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A synthetic kinematic index of trunk displacement conveying the overall motor condition in Parkinson’s disease

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