∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manne...

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Autores principales: Hamish Campbell, Nicholas Fleming, Imogen Roth, Sunali Mehta, Anna Wiles, Gail Williams, Claire Vennin, Nikola Arsic, Ashleigh Parkin, Marina Pajic, Fran Munro, Les McNoe, Michael Black, John McCall, Tania L. Slatter, Paul Timpson, Roger Reddel, Pierre Roux, Cristin Print, Margaret A. Baird, Antony W. Braithwaite
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4c1f6ec1d79b419c8e9e3bfbf63ac5e5
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spelling oai:doaj.org-article:4c1f6ec1d79b419c8e9e3bfbf63ac5e52021-12-02T15:33:35Z∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling10.1038/s41467-017-02408-02041-1723https://doaj.org/article/4c1f6ec1d79b419c8e9e3bfbf63ac5e52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02408-0https://doaj.org/toc/2041-1723Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manner.Hamish CampbellNicholas FlemingImogen RothSunali MehtaAnna WilesGail WilliamsClaire VenninNikola ArsicAshleigh ParkinMarina PajicFran MunroLes McNoeMichael BlackJohn McCallTania L. SlatterPaul TimpsonRoger ReddelPierre RouxCristin PrintMargaret A. BairdAntony W. BraithwaiteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hamish Campbell
Nicholas Fleming
Imogen Roth
Sunali Mehta
Anna Wiles
Gail Williams
Claire Vennin
Nikola Arsic
Ashleigh Parkin
Marina Pajic
Fran Munro
Les McNoe
Michael Black
John McCall
Tania L. Slatter
Paul Timpson
Roger Reddel
Pierre Roux
Cristin Print
Margaret A. Baird
Antony W. Braithwaite
∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
description Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manner.
format article
author Hamish Campbell
Nicholas Fleming
Imogen Roth
Sunali Mehta
Anna Wiles
Gail Williams
Claire Vennin
Nikola Arsic
Ashleigh Parkin
Marina Pajic
Fran Munro
Les McNoe
Michael Black
John McCall
Tania L. Slatter
Paul Timpson
Roger Reddel
Pierre Roux
Cristin Print
Margaret A. Baird
Antony W. Braithwaite
author_facet Hamish Campbell
Nicholas Fleming
Imogen Roth
Sunali Mehta
Anna Wiles
Gail Williams
Claire Vennin
Nikola Arsic
Ashleigh Parkin
Marina Pajic
Fran Munro
Les McNoe
Michael Black
John McCall
Tania L. Slatter
Paul Timpson
Roger Reddel
Pierre Roux
Cristin Print
Margaret A. Baird
Antony W. Braithwaite
author_sort Hamish Campbell
title ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
title_short ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
title_full ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
title_fullStr ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
title_full_unstemmed ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
title_sort ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of jak-stat and rhoa-rock signalling
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4c1f6ec1d79b419c8e9e3bfbf63ac5e5
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