Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer

Mengqi Sun,1 Yuchen Duan,2 Yumeng Ma,3 Qingyuan Zhang1 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang,...

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Autores principales:	Sun M, Duan Y, Ma Y, Zhang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	gold nanocages biomimetic cancer cell-erythrocyte radiation sensitization combined therapies breast cancer. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4c1fd6fad8a14841be683b18f5d7d2ce
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spelling	oai:doaj.org-article:4c1fd6fad8a14841be683b18f5d7d2ce2021-12-02T11:15:32ZCancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer1178-2013https://doaj.org/article/4c1fd6fad8a14841be683b18f5d7d2ce2020-09-01T00:00:00Zhttps://www.dovepress.com/cancer-cell-erythrocyte-hybrid-membrane-coated-gold-nanocages-for-near-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mengqi Sun,1 Yuchen Duan,2 Yumeng Ma,3 Qingyuan Zhang1 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China; 3Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of ChinaCorrespondence: Qingyuan Zhang Department of Medical OncologyHarbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of ChinaTel/Fax +86-0451-86298333Email zhangqingyuan@hrbmu.edu.cnBackground: The combination of radiotherapy (RT) and chemotherapy, as a standard treatment for breast cancer in the clinic, is unsatisfactory due to chemoradioresistance and severe side effects.Methods and Results: To address these issues, a cancer cell-erythrocyte hybrid membrane-coated doxorubicin (DOX)-loaded gold nanocage (CM-EM-GNCs@DOX) was constructed for near-infrared light (NIR)-activated photothermal/radio/chemotherapy of breast cancer. CM-EM-GNCs@DOX inherited an excellent homologous target ability from the cancer cell membrane and an immune evasion capability from the erythrocyte membrane, together resulting in highly efficient accumulation in the tumor site with decreased clearance. Following the highly efficient uptake of CM-EM-GNCs@DOX in cancer cells, the RT efficacy was remarkably amplified due to the radiosensitization effect of CM-EM-GNCs@DOX, which reduced the needed radiotherapeutic dose. Importantly, with NIR irradiation, CM-EM-GNCs@DOX exerted a high photothermal effect, which not only ruptured CM-EM-GNCs@DOX to release DOX for precise and controllable chemotherapy, but also potentiated chemo/radiotherapy by photothermal therapy.Conclusion: Therefore, a highly efficient and safe combined photothermal/radio/chemotherapy approach was achieved in vitro and in vivo by CM-EM-GNCs@DOX, which provided a promising strategy for treating breast cancer.Keywords: gold nanocages, biomimetic, cancer cell-erythrocyte, radiation sensitization, combined therapies, breast cancerSun MDuan YMa YZhang QDove Medical Pressarticlegold nanocagesbiomimeticcancer cell-erythrocyteradiation sensitizationcombined therapiesbreast cancer.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6749-6760 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gold nanocages biomimetic cancer cell-erythrocyte radiation sensitization combined therapies breast cancer. Medicine (General) R5-920
spellingShingle	gold nanocages biomimetic cancer cell-erythrocyte radiation sensitization combined therapies breast cancer. Medicine (General) R5-920 Sun M Duan Y Ma Y Zhang Q Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
description	Mengqi Sun,1 Yuchen Duan,2 Yumeng Ma,3 Qingyuan Zhang1 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China; 3Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of ChinaCorrespondence: Qingyuan Zhang Department of Medical OncologyHarbin Medical University Cancer Hospital, Harbin, Heilongjiang, People’s Republic of ChinaTel/Fax +86-0451-86298333Email zhangqingyuan@hrbmu.edu.cnBackground: The combination of radiotherapy (RT) and chemotherapy, as a standard treatment for breast cancer in the clinic, is unsatisfactory due to chemoradioresistance and severe side effects.Methods and Results: To address these issues, a cancer cell-erythrocyte hybrid membrane-coated doxorubicin (DOX)-loaded gold nanocage (CM-EM-GNCs@DOX) was constructed for near-infrared light (NIR)-activated photothermal/radio/chemotherapy of breast cancer. CM-EM-GNCs@DOX inherited an excellent homologous target ability from the cancer cell membrane and an immune evasion capability from the erythrocyte membrane, together resulting in highly efficient accumulation in the tumor site with decreased clearance. Following the highly efficient uptake of CM-EM-GNCs@DOX in cancer cells, the RT efficacy was remarkably amplified due to the radiosensitization effect of CM-EM-GNCs@DOX, which reduced the needed radiotherapeutic dose. Importantly, with NIR irradiation, CM-EM-GNCs@DOX exerted a high photothermal effect, which not only ruptured CM-EM-GNCs@DOX to release DOX for precise and controllable chemotherapy, but also potentiated chemo/radiotherapy by photothermal therapy.Conclusion: Therefore, a highly efficient and safe combined photothermal/radio/chemotherapy approach was achieved in vitro and in vivo by CM-EM-GNCs@DOX, which provided a promising strategy for treating breast cancer.Keywords: gold nanocages, biomimetic, cancer cell-erythrocyte, radiation sensitization, combined therapies, breast cancer
format	article
author	Sun M Duan Y Ma Y Zhang Q
author_facet	Sun M Duan Y Ma Y Zhang Q
author_sort	Sun M
title	Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
title_short	Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
title_full	Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
title_fullStr	Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
title_full_unstemmed	Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer
title_sort	cancer cell-erythrocyte hybrid membrane coated gold nanocages for near infrared light-activated photothermal/radio/chemotherapy of breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/4c1fd6fad8a14841be683b18f5d7d2ce
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Cancer Cell-Erythrocyte Hybrid Membrane Coated Gold Nanocages for Near Infrared Light-Activated Photothermal/Radio/Chemotherapy of Breast Cancer

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