USP35 regulates mitotic progression by modulating the stability of Aurora B

Aurora B kinase is a member of the chromosomal passenger complex, which is an indispensable regulator of mitosis. Here the authors show that the deubiquitinating enzyme USP35 has a role in mitotic progression by inhibiting proteasomal degradation of Aurora B kinase, leading to its activation.

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Autores principales:	Jinyoung Park, Mi-Sun Kwon, Eunice EunKyeong Kim, Hyunsook Lee, Eun Joo Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c23d20a9cb94e5ea9e1f1228d63465c
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spelling	oai:doaj.org-article:4c23d20a9cb94e5ea9e1f1228d63465c2021-12-02T16:49:32ZUSP35 regulates mitotic progression by modulating the stability of Aurora B10.1038/s41467-018-03107-02041-1723https://doaj.org/article/4c23d20a9cb94e5ea9e1f1228d63465c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03107-0https://doaj.org/toc/2041-1723Aurora B kinase is a member of the chromosomal passenger complex, which is an indispensable regulator of mitosis. Here the authors show that the deubiquitinating enzyme USP35 has a role in mitotic progression by inhibiting proteasomal degradation of Aurora B kinase, leading to its activation.Jinyoung ParkMi-Sun KwonEunice EunKyeong KimHyunsook LeeEun Joo SongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinyoung Park Mi-Sun Kwon Eunice EunKyeong Kim Hyunsook Lee Eun Joo Song USP35 regulates mitotic progression by modulating the stability of Aurora B
description	Aurora B kinase is a member of the chromosomal passenger complex, which is an indispensable regulator of mitosis. Here the authors show that the deubiquitinating enzyme USP35 has a role in mitotic progression by inhibiting proteasomal degradation of Aurora B kinase, leading to its activation.
format	article
author	Jinyoung Park Mi-Sun Kwon Eunice EunKyeong Kim Hyunsook Lee Eun Joo Song
author_facet	Jinyoung Park Mi-Sun Kwon Eunice EunKyeong Kim Hyunsook Lee Eun Joo Song
author_sort	Jinyoung Park
title	USP35 regulates mitotic progression by modulating the stability of Aurora B
title_short	USP35 regulates mitotic progression by modulating the stability of Aurora B
title_full	USP35 regulates mitotic progression by modulating the stability of Aurora B
title_fullStr	USP35 regulates mitotic progression by modulating the stability of Aurora B
title_full_unstemmed	USP35 regulates mitotic progression by modulating the stability of Aurora B
title_sort	usp35 regulates mitotic progression by modulating the stability of aurora b
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4c23d20a9cb94e5ea9e1f1228d63465c
work_keys_str_mv	AT jinyoungpark usp35regulatesmitoticprogressionbymodulatingthestabilityofaurorab AT misunkwon usp35regulatesmitoticprogressionbymodulatingthestabilityofaurorab AT euniceeunkyeongkim usp35regulatesmitoticprogressionbymodulatingthestabilityofaurorab AT hyunsooklee usp35regulatesmitoticprogressionbymodulatingthestabilityofaurorab AT eunjoosong usp35regulatesmitoticprogressionbymodulatingthestabilityofaurorab
_version_	1718383276684476416

USP35 regulates mitotic progression by modulating the stability of Aurora B

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