Structural and biomechanical basis of mitochondrial movement in eukaryotic cells

Min Wu,1 Aruna Kalyanasundaram,2 Jie Zhu1 1Laboratory of Biomechanics and Engineering, Institute of Biophysics, College of Science, Northwest A&F University, Yangling, Shaanxi, People's Republic of China; 2College of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA A...

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Autores principales:	Wu M, Kalyanasundaram A, Zhu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4c263eb00afe4d07844dba98fd84d38f
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spelling	oai:doaj.org-article:4c263eb00afe4d07844dba98fd84d38f2021-12-02T06:31:59ZStructural and biomechanical basis of mitochondrial movement in eukaryotic cells1176-91141178-2013https://doaj.org/article/4c263eb00afe4d07844dba98fd84d38f2013-10-01T00:00:00Zhttp://www.dovepress.com/structural-and-biomechanical-basis-of-mitochondrial-movement-in-eukary-a14783https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Min Wu,1 Aruna Kalyanasundaram,2 Jie Zhu1 1Laboratory of Biomechanics and Engineering, Institute of Biophysics, College of Science, Northwest A&F University, Yangling, Shaanxi, People's Republic of China; 2College of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA Abstract: Mitochondria serve as energy-producing organelles in eukaryotic cells. In addition to providing the energy supply for cells, the mitochondria are also involved in other processes, such as proliferation, differentiation, information transfer, and apoptosis, and play an important role in regulation of cell growth and the cell cycle. In order to achieve these functions, the mitochondria need to move to the corresponding location. Therefore, mitochondrial movement has a crucial role in normal physiologic activity, and any mitochondrial movement disorder will cause irreparable damage to the organism. For example, recent studies have shown that abnormal movement of the mitochondria is likely to be the reason for Charcot–Marie–Tooth disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, and schizophrenia. So, in the cell, especially in the particular polarized cell, the appropriate distribution of mitochondria is crucial to the function and survival of the cell. Mitochondrial movement is mainly associated with the cytoskeleton and related proteins. However, those components play different roles according to cell type. In this paper, we summarize the structural basis of mitochondrial movement, including microtubules, actin filaments, motor proteins, and adaptin, and review studies of the biomechanical mechanisms of mitochondrial movement in different types of cells. Keywords: mitochondrial movement, microtubules, actin filaments, motor proteins, adaptinWu MKalyanasundaram AZhu JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4033-4042 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wu M Kalyanasundaram A Zhu J Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
description	Min Wu,1 Aruna Kalyanasundaram,2 Jie Zhu1 1Laboratory of Biomechanics and Engineering, Institute of Biophysics, College of Science, Northwest A&F University, Yangling, Shaanxi, People's Republic of China; 2College of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA Abstract: Mitochondria serve as energy-producing organelles in eukaryotic cells. In addition to providing the energy supply for cells, the mitochondria are also involved in other processes, such as proliferation, differentiation, information transfer, and apoptosis, and play an important role in regulation of cell growth and the cell cycle. In order to achieve these functions, the mitochondria need to move to the corresponding location. Therefore, mitochondrial movement has a crucial role in normal physiologic activity, and any mitochondrial movement disorder will cause irreparable damage to the organism. For example, recent studies have shown that abnormal movement of the mitochondria is likely to be the reason for Charcot–Marie–Tooth disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, and schizophrenia. So, in the cell, especially in the particular polarized cell, the appropriate distribution of mitochondria is crucial to the function and survival of the cell. Mitochondrial movement is mainly associated with the cytoskeleton and related proteins. However, those components play different roles according to cell type. In this paper, we summarize the structural basis of mitochondrial movement, including microtubules, actin filaments, motor proteins, and adaptin, and review studies of the biomechanical mechanisms of mitochondrial movement in different types of cells. Keywords: mitochondrial movement, microtubules, actin filaments, motor proteins, adaptin
format	article
author	Wu M Kalyanasundaram A Zhu J
author_facet	Wu M Kalyanasundaram A Zhu J
author_sort	Wu M
title	Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
title_short	Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
title_full	Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
title_fullStr	Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
title_full_unstemmed	Structural and biomechanical basis of mitochondrial movement in eukaryotic cells
title_sort	structural and biomechanical basis of mitochondrial movement in eukaryotic cells
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/4c263eb00afe4d07844dba98fd84d38f
work_keys_str_mv	AT wum structuralandbiomechanicalbasisofmitochondrialmovementineukaryoticcells AT kalyanasundarama structuralandbiomechanicalbasisofmitochondrialmovementineukaryoticcells AT zhuj structuralandbiomechanicalbasisofmitochondrialmovementineukaryoticcells
_version_	1718399868965224448

Structural and biomechanical basis of mitochondrial movement in eukaryotic cells

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