A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans

Abstract Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attra...

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Autores principales:	Donha Park, Jeong-Hoon Hahm, Saeram Park, Go Ha, Gyeong-Eon Chang, Haelim Jeong, Heekyeong Kim, Sunhee Kim, Eunji Cheong, Young-Ki Paik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c270f64486946e9a070a143e78034ee
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spelling	oai:doaj.org-article:4c270f64486946e9a070a143e78034ee2021-12-02T11:52:28ZA conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans10.1038/s41598-017-07313-62045-2322https://doaj.org/article/4c270f64486946e9a070a143e78034ee2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07313-6https://doaj.org/toc/2045-2322Abstract Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival.Donha ParkJeong-Hoon HahmSaeram ParkGo HaGyeong-Eon ChangHaelim JeongHeekyeong KimSunhee KimEunji CheongYoung-Ki PaikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Donha Park Jeong-Hoon Hahm Saeram Park Go Ha Gyeong-Eon Chang Haelim Jeong Heekyeong Kim Sunhee Kim Eunji Cheong Young-Ki Paik A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
description	Abstract Animals use pheromones as a conspecific chemical language to respond appropriately to environmental changes. The soil nematode Caenorhabditis elegans secretes ascaroside pheromones throughout the lifecycle, which influences entry into dauer phase in early larvae, in addition to sexual attraction and aggregation. In adult hermaphrodites, pheromone sensory signals perceived by worms usually elicit repulsion as an initial behavioral signature. However, the molecular mechanisms underlying neuronal pheromone sensory process from perception to repulsion in adult hermaphrodites remain poorly understood. Here, we show that pheromone signals perceived by GPA-3 is conveyed through glutamatergic neurotransmission in which neuronal DAF-16/FoxO plays an important modulatory role by controlling glutaminase gene expression. We further provide evidence that this modulatory role for DAF-16/FoxO seems to be conserved evolutionarily by electro-physiological study in mouse primary hippocampal neurons that are responsible for glutamatergic neurotransmission. These findings provide the basis for understanding the nematode pheromone signaling, which seems crucial for adaptation of adult hermaphrodites to changes in environmental condition for survival.
format	article
author	Donha Park Jeong-Hoon Hahm Saeram Park Go Ha Gyeong-Eon Chang Haelim Jeong Heekyeong Kim Sunhee Kim Eunji Cheong Young-Ki Paik
author_facet	Donha Park Jeong-Hoon Hahm Saeram Park Go Ha Gyeong-Eon Chang Haelim Jeong Heekyeong Kim Sunhee Kim Eunji Cheong Young-Ki Paik
author_sort	Donha Park
title	A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
title_short	A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
title_full	A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
title_fullStr	A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
title_full_unstemmed	A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans
title_sort	conserved neuronal daf-16/foxo plays an important role in conveying pheromone signals to elicit repulsion behavior in caenorhabditis elegans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c270f64486946e9a070a143e78034ee
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A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans

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