Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation energy barrier in tubulin-tubulin interaction...

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Autores principales:	Nikita B. Gudimchuk, Evgeni V. Ulyanov, Eileen O’Toole, Cynthia L. Page, Dmitrii S. Vinogradov, Garry Morgan, Gabriella Li, Jeffrey K. Moore, Ewa Szczesna, Antonina Roll-Mecak, Fazoil I. Ataullakhanov, J. Richard McIntosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c2a69ba2077454289ab669fcc7b5686
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spelling	oai:doaj.org-article:4c2a69ba2077454289ab669fcc7b56862021-12-02T18:47:05ZMechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography10.1038/s41467-020-17553-22041-1723https://doaj.org/article/4c2a69ba2077454289ab669fcc7b56862020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17553-2https://doaj.org/toc/2041-1723Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation energy barrier in tubulin-tubulin interactions is a key parameter for this process, controlling the development of high pulling forces.Nikita B. GudimchukEvgeni V. UlyanovEileen O’TooleCynthia L. PageDmitrii S. VinogradovGarry MorganGabriella LiJeffrey K. MooreEwa SzczesnaAntonina Roll-MecakFazoil I. AtaullakhanovJ. Richard McIntoshNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikita B. Gudimchuk Evgeni V. Ulyanov Eileen O’Toole Cynthia L. Page Dmitrii S. Vinogradov Garry Morgan Gabriella Li Jeffrey K. Moore Ewa Szczesna Antonina Roll-Mecak Fazoil I. Ataullakhanov J. Richard McIntosh Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
description	Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation energy barrier in tubulin-tubulin interactions is a key parameter for this process, controlling the development of high pulling forces.
format	article
author	Nikita B. Gudimchuk Evgeni V. Ulyanov Eileen O’Toole Cynthia L. Page Dmitrii S. Vinogradov Garry Morgan Gabriella Li Jeffrey K. Moore Ewa Szczesna Antonina Roll-Mecak Fazoil I. Ataullakhanov J. Richard McIntosh
author_facet	Nikita B. Gudimchuk Evgeni V. Ulyanov Eileen O’Toole Cynthia L. Page Dmitrii S. Vinogradov Garry Morgan Gabriella Li Jeffrey K. Moore Ewa Szczesna Antonina Roll-Mecak Fazoil I. Ataullakhanov J. Richard McIntosh
author_sort	Nikita B. Gudimchuk
title	Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
title_short	Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
title_full	Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
title_fullStr	Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
title_full_unstemmed	Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
title_sort	mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c2a69ba2077454289ab669fcc7b5686
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Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

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