Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography

Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation energy barrier in tubulin-tubulin interaction...

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Autores principales: Nikita B. Gudimchuk, Evgeni V. Ulyanov, Eileen O’Toole, Cynthia L. Page, Dmitrii S. Vinogradov, Garry Morgan, Gabriella Li, Jeffrey K. Moore, Ewa Szczesna, Antonina Roll-Mecak, Fazoil I. Ataullakhanov, J. Richard McIntosh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/4c2a69ba2077454289ab669fcc7b5686
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