Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfuncti...
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Nature Portfolio
2019
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oai:doaj.org-article:4c3223da69ca4524955a319f2fa0179d2021-12-02T14:39:03ZMitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities10.1038/s41467-019-13694-12041-1723https://doaj.org/article/4c3223da69ca4524955a319f2fa0179d2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13694-1https://doaj.org/toc/2041-1723Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia.Eugenia MigliavaccaStacey K. H. TayHarnish P. PatelTanja SonntagGabriele CivilettoCraig McFarlaneTerence ForresterSheila J. BartonMelvin K. LeowElie AntounAline CharpagneYap Seng ChongPatrick DescombesLei FengPatrice Francis-EmmanuelEmma S. GarrattMaria Pilar GinerCurtis O. GreenSonia KarazNarasimhan KothandaramanJulien MarquisSylviane MetaironSofia MocoGail NelsonSherry NgoTony PleasantsFrederic RaymondAvan A. SayerChu Ming SimJo Slater-JefferiesHolly E. SyddallPei Fang TanPhilip TitcombeCandida VazLeo D. WestburyGerard WongWu YonghuiCyrus CooperAllan SheppardKeith M. GodfreyKaren A. LillycropNeerja KarnaniJerome N. FeigeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q Eugenia Migliavacca Stacey K. H. Tay Harnish P. Patel Tanja Sonntag Gabriele Civiletto Craig McFarlane Terence Forrester Sheila J. Barton Melvin K. Leow Elie Antoun Aline Charpagne Yap Seng Chong Patrick Descombes Lei Feng Patrice Francis-Emmanuel Emma S. Garratt Maria Pilar Giner Curtis O. Green Sonia Karaz Narasimhan Kothandaraman Julien Marquis Sylviane Metairon Sofia Moco Gail Nelson Sherry Ngo Tony Pleasants Frederic Raymond Avan A. Sayer Chu Ming Sim Jo Slater-Jefferies Holly E. Syddall Pei Fang Tan Philip Titcombe Candida Vaz Leo D. Westbury Gerard Wong Wu Yonghui Cyrus Cooper Allan Sheppard Keith M. Godfrey Karen A. Lillycrop Neerja Karnani Jerome N. Feige Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| description |
Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia. |
| format |
article |
| author |
Eugenia Migliavacca Stacey K. H. Tay Harnish P. Patel Tanja Sonntag Gabriele Civiletto Craig McFarlane Terence Forrester Sheila J. Barton Melvin K. Leow Elie Antoun Aline Charpagne Yap Seng Chong Patrick Descombes Lei Feng Patrice Francis-Emmanuel Emma S. Garratt Maria Pilar Giner Curtis O. Green Sonia Karaz Narasimhan Kothandaraman Julien Marquis Sylviane Metairon Sofia Moco Gail Nelson Sherry Ngo Tony Pleasants Frederic Raymond Avan A. Sayer Chu Ming Sim Jo Slater-Jefferies Holly E. Syddall Pei Fang Tan Philip Titcombe Candida Vaz Leo D. Westbury Gerard Wong Wu Yonghui Cyrus Cooper Allan Sheppard Keith M. Godfrey Karen A. Lillycrop Neerja Karnani Jerome N. Feige |
| author_facet |
Eugenia Migliavacca Stacey K. H. Tay Harnish P. Patel Tanja Sonntag Gabriele Civiletto Craig McFarlane Terence Forrester Sheila J. Barton Melvin K. Leow Elie Antoun Aline Charpagne Yap Seng Chong Patrick Descombes Lei Feng Patrice Francis-Emmanuel Emma S. Garratt Maria Pilar Giner Curtis O. Green Sonia Karaz Narasimhan Kothandaraman Julien Marquis Sylviane Metairon Sofia Moco Gail Nelson Sherry Ngo Tony Pleasants Frederic Raymond Avan A. Sayer Chu Ming Sim Jo Slater-Jefferies Holly E. Syddall Pei Fang Tan Philip Titcombe Candida Vaz Leo D. Westbury Gerard Wong Wu Yonghui Cyrus Cooper Allan Sheppard Keith M. Godfrey Karen A. Lillycrop Neerja Karnani Jerome N. Feige |
| author_sort |
Eugenia Migliavacca |
| title |
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| title_short |
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| title_full |
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| title_fullStr |
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| title_full_unstemmed |
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities |
| title_sort |
mitochondrial oxidative capacity and nad+ biosynthesis are reduced in human sarcopenia across ethnicities |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4c3223da69ca4524955a319f2fa0179d |
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