Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection

Introduction: Children commonly present in diabetic ketoacidosis (DKA) secondary to Type 1 diabetes mellitus. Electrolyte imbalances and cerebral edema are common complications in the pediatric age group; however, patients may also have additional metabolic disturbances such as hyperlipidemia. We re...

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Autores principales:	Caroline Basta, Kristen Ramones, Saranga Agarwal, Gina Marino, Steven Ghanny
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diabetic ketoacidosis Hypertriglyceridemia SARS-CoV-2 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/4c33b0ccfe7b48f7993afe5d2cadd528
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spelling	oai:doaj.org-article:4c33b0ccfe7b48f7993afe5d2cadd5282021-11-12T04:34:53ZSevere hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection2214-624510.1016/j.jecr.2021.100099https://doaj.org/article/4c33b0ccfe7b48f7993afe5d2cadd5282021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214624521000228https://doaj.org/toc/2214-6245Introduction: Children commonly present in diabetic ketoacidosis (DKA) secondary to Type 1 diabetes mellitus. Electrolyte imbalances and cerebral edema are common complications in the pediatric age group; however, patients may also have additional metabolic disturbances such as hyperlipidemia. We report a case of a pediatric patient with new-onset type 1 Diabetes Mellitus (DM) and DKA complicated by severe hypertriglyceridemia with recent exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Case presentation: A three-year-old male noted to be SARS-CoV-2 positive, presented with hyperglycemia, metabolic acidosis, and ketosis consistent with DKA. Patient was later found to have severe hypertriglyceridemia (greater than 5680 mg/dL). He was managed with intravenous (IV) fluids and IV insulin replacement with improvement of triglycerides. Conclusion: Severe hypertriglyceridemia in DKA, though rare in the pediatric population, responds very well to IV insulin therapy. This case also highlights possible need for early lipid screening in DKA patients with SARS-CoV-2 positive status.Caroline BastaKristen RamonesSaranga AgarwalGina MarinoSteven GhannyElsevierarticleDiabetic ketoacidosisHypertriglyceridemiaSARS-CoV-2Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJournal of Clinical and Translational Endocrinology Case Reports, Vol 22, Iss , Pp 100099- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetic ketoacidosis Hypertriglyceridemia SARS-CoV-2 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diabetic ketoacidosis Hypertriglyceridemia SARS-CoV-2 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Caroline Basta Kristen Ramones Saranga Agarwal Gina Marino Steven Ghanny Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
description	Introduction: Children commonly present in diabetic ketoacidosis (DKA) secondary to Type 1 diabetes mellitus. Electrolyte imbalances and cerebral edema are common complications in the pediatric age group; however, patients may also have additional metabolic disturbances such as hyperlipidemia. We report a case of a pediatric patient with new-onset type 1 Diabetes Mellitus (DM) and DKA complicated by severe hypertriglyceridemia with recent exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Case presentation: A three-year-old male noted to be SARS-CoV-2 positive, presented with hyperglycemia, metabolic acidosis, and ketosis consistent with DKA. Patient was later found to have severe hypertriglyceridemia (greater than 5680 mg/dL). He was managed with intravenous (IV) fluids and IV insulin replacement with improvement of triglycerides. Conclusion: Severe hypertriglyceridemia in DKA, though rare in the pediatric population, responds very well to IV insulin therapy. This case also highlights possible need for early lipid screening in DKA patients with SARS-CoV-2 positive status.
format	article
author	Caroline Basta Kristen Ramones Saranga Agarwal Gina Marino Steven Ghanny
author_facet	Caroline Basta Kristen Ramones Saranga Agarwal Gina Marino Steven Ghanny
author_sort	Caroline Basta
title	Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
title_short	Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
title_full	Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
title_fullStr	Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
title_full_unstemmed	Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection
title_sort	severe hypertriglyceridemia: a rare complication of diabetic ketoacidosis in a 3-year-old with sars-cov-2 infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4c33b0ccfe7b48f7993afe5d2cadd528
work_keys_str_mv	AT carolinebasta severehypertriglyceridemiaararecomplicationofdiabeticketoacidosisina3yearoldwithsarscov2infection AT kristenramones severehypertriglyceridemiaararecomplicationofdiabeticketoacidosisina3yearoldwithsarscov2infection AT sarangaagarwal severehypertriglyceridemiaararecomplicationofdiabeticketoacidosisina3yearoldwithsarscov2infection AT ginamarino severehypertriglyceridemiaararecomplicationofdiabeticketoacidosisina3yearoldwithsarscov2infection AT stevenghanny severehypertriglyceridemiaararecomplicationofdiabeticketoacidosisina3yearoldwithsarscov2infection
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Severe hypertriglyceridemia: A rare complication of diabetic ketoacidosis in a 3-year-old with SARS-CoV-2 infection

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