“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus

Gene tandem amplifications can drive bacterial evolution. Here, Belikova et al. identify copy number variations of lipoprotein-encoding genes in Staphylococcus aureus clinical isolates, and show that the loci expand and contract during bacterial growth in vitro and in mice, leading to changes in imm...

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Autores principales:	Darya Belikova, Angelika Jochim, Jeffrey Power, Matthew T. G. Holden, Simon Heilbronner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c383d564aab421693bdf9003b5298d4
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spelling	oai:doaj.org-article:4c383d564aab421693bdf9003b5298d42021-12-02T15:33:05Z“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus10.1038/s41467-020-17277-32041-1723https://doaj.org/article/4c383d564aab421693bdf9003b5298d42020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17277-3https://doaj.org/toc/2041-1723Gene tandem amplifications can drive bacterial evolution. Here, Belikova et al. identify copy number variations of lipoprotein-encoding genes in Staphylococcus aureus clinical isolates, and show that the loci expand and contract during bacterial growth in vitro and in mice, leading to changes in immunostimulatory capacity.Darya BelikovaAngelika JochimJeffrey PowerMatthew T. G. HoldenSimon HeilbronnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Darya Belikova Angelika Jochim Jeffrey Power Matthew T. G. Holden Simon Heilbronner “Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
description	Gene tandem amplifications can drive bacterial evolution. Here, Belikova et al. identify copy number variations of lipoprotein-encoding genes in Staphylococcus aureus clinical isolates, and show that the loci expand and contract during bacterial growth in vitro and in mice, leading to changes in immunostimulatory capacity.
format	article
author	Darya Belikova Angelika Jochim Jeffrey Power Matthew T. G. Holden Simon Heilbronner
author_facet	Darya Belikova Angelika Jochim Jeffrey Power Matthew T. G. Holden Simon Heilbronner
author_sort	Darya Belikova
title	“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
title_short	“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
title_full	“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
title_fullStr	“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
title_full_unstemmed	“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus
title_sort	“gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of staphylococcus aureus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c383d564aab421693bdf9003b5298d4
work_keys_str_mv	AT daryabelikova geneaccordionscausegenotypicandphenotypicheterogeneityinclonalpopulationsofstaphylococcusaureus AT angelikajochim geneaccordionscausegenotypicandphenotypicheterogeneityinclonalpopulationsofstaphylococcusaureus AT jeffreypower geneaccordionscausegenotypicandphenotypicheterogeneityinclonalpopulationsofstaphylococcusaureus AT matthewtgholden geneaccordionscausegenotypicandphenotypicheterogeneityinclonalpopulationsofstaphylococcusaureus AT simonheilbronner geneaccordionscausegenotypicandphenotypicheterogeneityinclonalpopulationsofstaphylococcusaureus
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“Gene accordions” cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus

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