Cardiac macrophages prevent sudden death during heart stress

Cardiac immune cells play various roles in the maintenance of homeostasis and diseases in the heart. Here the authors show that cardiac resident macrophages are a critical regulator of cardiac impulse conduction through amphiregulin production, contributing to the prevention of sudden death.

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Autores principales:	Junichi Sugita, Katsuhito Fujiu, Yukiteru Nakayama, Takumi Matsubara, Jun Matsuda, Tsukasa Oshima, Yuxiang Liu, Yujin Maru, Eriko Hasumi, Toshiya Kojima, Hiroshi Seno, Keisuke Asano, Ayumu Ishijima, Naoki Tomii, Masatoshi Yamazaki, Fujimi Kudo, Ichiro Sakuma, Ryozo Nagai, Ichiro Manabe, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c3a1db08c0f44869b3b847bdde1ec4c
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spelling	oai:doaj.org-article:4c3a1db08c0f44869b3b847bdde1ec4c2021-12-02T17:04:30ZCardiac macrophages prevent sudden death during heart stress10.1038/s41467-021-22178-02041-1723https://doaj.org/article/4c3a1db08c0f44869b3b847bdde1ec4c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22178-0https://doaj.org/toc/2041-1723Cardiac immune cells play various roles in the maintenance of homeostasis and diseases in the heart. Here the authors show that cardiac resident macrophages are a critical regulator of cardiac impulse conduction through amphiregulin production, contributing to the prevention of sudden death.Junichi SugitaKatsuhito FujiuYukiteru NakayamaTakumi MatsubaraJun MatsudaTsukasa OshimaYuxiang LiuYujin MaruEriko HasumiToshiya KojimaHiroshi SenoKeisuke AsanoAyumu IshijimaNaoki TomiiMasatoshi YamazakiFujimi KudoIchiro SakumaRyozo NagaiIchiro ManabeIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junichi Sugita Katsuhito Fujiu Yukiteru Nakayama Takumi Matsubara Jun Matsuda Tsukasa Oshima Yuxiang Liu Yujin Maru Eriko Hasumi Toshiya Kojima Hiroshi Seno Keisuke Asano Ayumu Ishijima Naoki Tomii Masatoshi Yamazaki Fujimi Kudo Ichiro Sakuma Ryozo Nagai Ichiro Manabe Issei Komuro Cardiac macrophages prevent sudden death during heart stress
description	Cardiac immune cells play various roles in the maintenance of homeostasis and diseases in the heart. Here the authors show that cardiac resident macrophages are a critical regulator of cardiac impulse conduction through amphiregulin production, contributing to the prevention of sudden death.
format	article
author	Junichi Sugita Katsuhito Fujiu Yukiteru Nakayama Takumi Matsubara Jun Matsuda Tsukasa Oshima Yuxiang Liu Yujin Maru Eriko Hasumi Toshiya Kojima Hiroshi Seno Keisuke Asano Ayumu Ishijima Naoki Tomii Masatoshi Yamazaki Fujimi Kudo Ichiro Sakuma Ryozo Nagai Ichiro Manabe Issei Komuro
author_facet	Junichi Sugita Katsuhito Fujiu Yukiteru Nakayama Takumi Matsubara Jun Matsuda Tsukasa Oshima Yuxiang Liu Yujin Maru Eriko Hasumi Toshiya Kojima Hiroshi Seno Keisuke Asano Ayumu Ishijima Naoki Tomii Masatoshi Yamazaki Fujimi Kudo Ichiro Sakuma Ryozo Nagai Ichiro Manabe Issei Komuro
author_sort	Junichi Sugita
title	Cardiac macrophages prevent sudden death during heart stress
title_short	Cardiac macrophages prevent sudden death during heart stress
title_full	Cardiac macrophages prevent sudden death during heart stress
title_fullStr	Cardiac macrophages prevent sudden death during heart stress
title_full_unstemmed	Cardiac macrophages prevent sudden death during heart stress
title_sort	cardiac macrophages prevent sudden death during heart stress
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c3a1db08c0f44869b3b847bdde1ec4c
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Cardiac macrophages prevent sudden death during heart stress

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