Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy

The purpose of this review is to analyze existing data on the molecular genetic features of the development of type 1 and type 2 diabetes mellitus, gestational diabetes and specific types of diabetes (maturity onset of diabetes of the young, neоnatal diabetes) and to assess the possibility of precis...

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Autores principales:	Tatyana Yu. Demidova, Svetlana G. Zenina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	precision medicine diabetes mellitus mody diabetes neonatal diabetes genetics pharmacogenomics Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4c414e292d814e23a2be1b121e625c4e
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id	oai:doaj.org-article:4c414e292d814e23a2be1b121e625c4e
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spelling	oai:doaj.org-article:4c414e292d814e23a2be1b121e625c4e2021-11-14T09:00:23ZMolecular genetic features of the diabetes mellitus development and the possibility of precision therapy2072-03512072-037810.14341/DM12486https://doaj.org/article/4c414e292d814e23a2be1b121e625c4e2021-01-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12486https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The purpose of this review is to analyze existing data on the molecular genetic features of the development of type 1 and type 2 diabetes mellitus, gestational diabetes and specific types of diabetes (maturity onset of diabetes of the young, neоnatal diabetes) and to assess the possibility of precision therapy.The etiology of diabetes is heterogeneous, and a genetic predisposition plays a significant role in its development. Genetic studies, conducted in the past few decades, allow us to identify a number of genes that directly affect the development of diabetes. The genetic prerequisites indicate high levels of predictability for the occurrence of type 1 diabetes. The only personalized treatment that is known to date for such patients is insulin therapy. For monogenic specific types of diabetes, genetic testing is a diagnostic factor which allows to prescribe adequate therapy. The molecular genetic characteristics of the development of type 2 diabetes and gestational diabetes are very complex and ambiguous, however, the existing rich data will become the basis for future recommendations for the prevention, diagnosis and personalized treatment.Tatyana Yu. DemidovaSvetlana G. ZeninaEndocrinology Research Centrearticleprecision medicinediabetes mellitusmody diabetesneonatal diabetesgeneticspharmacogenomicsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 5, Pp 467-474 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	precision medicine diabetes mellitus mody diabetes neonatal diabetes genetics pharmacogenomics Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	precision medicine diabetes mellitus mody diabetes neonatal diabetes genetics pharmacogenomics Nutritional diseases. Deficiency diseases RC620-627 Tatyana Yu. Demidova Svetlana G. Zenina Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
description	The purpose of this review is to analyze existing data on the molecular genetic features of the development of type 1 and type 2 diabetes mellitus, gestational diabetes and specific types of diabetes (maturity onset of diabetes of the young, neоnatal diabetes) and to assess the possibility of precision therapy.The etiology of diabetes is heterogeneous, and a genetic predisposition plays a significant role in its development. Genetic studies, conducted in the past few decades, allow us to identify a number of genes that directly affect the development of diabetes. The genetic prerequisites indicate high levels of predictability for the occurrence of type 1 diabetes. The only personalized treatment that is known to date for such patients is insulin therapy. For monogenic specific types of diabetes, genetic testing is a diagnostic factor which allows to prescribe adequate therapy. The molecular genetic characteristics of the development of type 2 diabetes and gestational diabetes are very complex and ambiguous, however, the existing rich data will become the basis for future recommendations for the prevention, diagnosis and personalized treatment.
format	article
author	Tatyana Yu. Demidova Svetlana G. Zenina
author_facet	Tatyana Yu. Demidova Svetlana G. Zenina
author_sort	Tatyana Yu. Demidova
title	Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
title_short	Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
title_full	Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
title_fullStr	Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
title_full_unstemmed	Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
title_sort	molecular genetic features of the diabetes mellitus development and the possibility of precision therapy
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/4c414e292d814e23a2be1b121e625c4e
work_keys_str_mv	AT tatyanayudemidova moleculargeneticfeaturesofthediabetesmellitusdevelopmentandthepossibilityofprecisiontherapy AT svetlanagzenina moleculargeneticfeaturesofthediabetesmellitusdevelopmentandthepossibilityofprecisiontherapy
_version_	1718429462098345984

Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy

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