Real-time functional magnetic resonance imaging in obsessive-compulsive disorder

Óscar F Gonçalves,1–3 Marcelo C Batistuzzo,4 João R Sato5 1Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal; 2Spaulding Neuromodulation Center, Department of Physical Medicine & Rehabilitation, Spaulding...

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Autores principales:	Gonçalves ÓF, Batistuzzo MC, Sato JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Real time fMRI Obsessive-compulsive disorder Self-Regulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4c423441c92e43c7882cbaf846a00f52
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spelling	oai:doaj.org-article:4c423441c92e43c7882cbaf846a00f522021-12-02T06:28:00ZReal-time functional magnetic resonance imaging in obsessive-compulsive disorder1178-2021https://doaj.org/article/4c423441c92e43c7882cbaf846a00f522017-07-01T00:00:00Zhttps://www.dovepress.com/real-time-functional-magnetic-resonance-imaging-in-obsessive-compulsiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Óscar F Gonçalves,1–3 Marcelo C Batistuzzo,4 João R Sato5 1Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal; 2Spaulding Neuromodulation Center, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 3Social and Cognitive Neuroscience Laboratory, Center for Health and Biological Sciences, Mackenzie Presbyterian University, 4Department and Institute of Psychiatry, University of São Paulo Medical School (FMUSP), 5Mathematics, Computing, and Cognition Center, Universidade Federal do ABC – UFABC, São Paulo, Brazil Abstract: The current literature provides substantial evidence of brain alterations associated with obsessive-compulsive disorder (OCD) symptoms (eg, checking, cleaning/decontamination, counting compulsions; harm or sexual, symmetry/exactness obsessions), and emotional problems (eg, defensive/appetitive emotional imbalance, disgust, guilt, shame, and fear learning/extinction) and cognitive impairments associated with this disorder (eg, inhibitory control, working memory, cognitive flexibility). Building on this evidence, new clinical trials can now target specific brain regions/networks. Real-time functional magnetic resonance imaging (rtfMRI) was introduced as a new therapeutic tool for the self-regulation of brain–mind. In this review, we describe initial trials testing the use of rtfMRI to target brain regions associated with specific OCD symptoms (eg, contamination), and other mind–brain processes (eg, cognitive – working memory, inhibitory control, emotional – defensive, appetitive systems, fear reduction through counter-conditioning) found impaired in OCD patients. While this is a novel topic of research, initial evidence shows the promise of using rtfMRI in training the self-regulation of brain regions and mental processes associated with OCD. Additionally, studies with healthy populations have shown that individuals can regulate brain regions associated with cognitive and emotional processes found impaired in OCD. After the initial “proof-of-concept” stage, there is a need to follow up with controlled clinical trials that could test rtfMRI innovative treatments targeting brain regions and networks associated with different OCD symptoms and cognitive-emotional impairments. Keywords: real-time fMRI, obsessive-compulsive disorder, self-regulation, neurofeedback, neuromodulationGonçalves ÓFBatistuzzo MCSato JRDove Medical PressarticleReal time fMRIObsessive-compulsive disorderSelf-RegulationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1825-1834 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Real time fMRI Obsessive-compulsive disorder Self-Regulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Real time fMRI Obsessive-compulsive disorder Self-Regulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gonçalves ÓF Batistuzzo MC Sato JR Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
description	Óscar F Gonçalves,1–3 Marcelo C Batistuzzo,4 João R Sato5 1Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal; 2Spaulding Neuromodulation Center, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 3Social and Cognitive Neuroscience Laboratory, Center for Health and Biological Sciences, Mackenzie Presbyterian University, 4Department and Institute of Psychiatry, University of São Paulo Medical School (FMUSP), 5Mathematics, Computing, and Cognition Center, Universidade Federal do ABC – UFABC, São Paulo, Brazil Abstract: The current literature provides substantial evidence of brain alterations associated with obsessive-compulsive disorder (OCD) symptoms (eg, checking, cleaning/decontamination, counting compulsions; harm or sexual, symmetry/exactness obsessions), and emotional problems (eg, defensive/appetitive emotional imbalance, disgust, guilt, shame, and fear learning/extinction) and cognitive impairments associated with this disorder (eg, inhibitory control, working memory, cognitive flexibility). Building on this evidence, new clinical trials can now target specific brain regions/networks. Real-time functional magnetic resonance imaging (rtfMRI) was introduced as a new therapeutic tool for the self-regulation of brain–mind. In this review, we describe initial trials testing the use of rtfMRI to target brain regions associated with specific OCD symptoms (eg, contamination), and other mind–brain processes (eg, cognitive – working memory, inhibitory control, emotional – defensive, appetitive systems, fear reduction through counter-conditioning) found impaired in OCD patients. While this is a novel topic of research, initial evidence shows the promise of using rtfMRI in training the self-regulation of brain regions and mental processes associated with OCD. Additionally, studies with healthy populations have shown that individuals can regulate brain regions associated with cognitive and emotional processes found impaired in OCD. After the initial “proof-of-concept” stage, there is a need to follow up with controlled clinical trials that could test rtfMRI innovative treatments targeting brain regions and networks associated with different OCD symptoms and cognitive-emotional impairments. Keywords: real-time fMRI, obsessive-compulsive disorder, self-regulation, neurofeedback, neuromodulation
format	article
author	Gonçalves ÓF Batistuzzo MC Sato JR
author_facet	Gonçalves ÓF Batistuzzo MC Sato JR
author_sort	Gonçalves ÓF
title	Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
title_short	Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
title_full	Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
title_fullStr	Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
title_full_unstemmed	Real-time functional magnetic resonance imaging in obsessive-compulsive disorder
title_sort	real-time functional magnetic resonance imaging in obsessive-compulsive disorder
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4c423441c92e43c7882cbaf846a00f52
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_version_	1718399869152919552

Real-time functional magnetic resonance imaging in obsessive-compulsive disorder

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