Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling

LUBAC is involved in adding linear ubiquitin chains to important immune signaling proteins. Here the authors show that this mechanism is effective in inhibiting STAT1-mediated interferon signaling, and that the deubiquitinase OTULIN can remove these linear ubiquitins from STAT1 to reactivate this an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yibo Zuo, Qian Feng, Lincong Jin, Fan Huang, Ying Miao, Jin Liu, Ying Xu, Xiangjie Chen, Hongguang Zhang, Tingting Guo, Yukang Yuan, Liting Zhang, Jun Wang, Hui Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c4454e0aa0248c9a214db9c6f0ed420
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4c4454e0aa0248c9a214db9c6f0ed420
record_format	dspace
spelling	oai:doaj.org-article:4c4454e0aa0248c9a214db9c6f0ed4202021-12-02T15:33:50ZRegulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling10.1038/s41467-020-14948-z2041-1723https://doaj.org/article/4c4454e0aa0248c9a214db9c6f0ed4202020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14948-zhttps://doaj.org/toc/2041-1723LUBAC is involved in adding linear ubiquitin chains to important immune signaling proteins. Here the authors show that this mechanism is effective in inhibiting STAT1-mediated interferon signaling, and that the deubiquitinase OTULIN can remove these linear ubiquitins from STAT1 to reactivate this antiviral signaling pathway.Yibo ZuoQian FengLincong JinFan HuangYing MiaoJin LiuYing XuXiangjie ChenHongguang ZhangTingting GuoYukang YuanLiting ZhangJun WangHui ZhengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yibo Zuo Qian Feng Lincong Jin Fan Huang Ying Miao Jin Liu Ying Xu Xiangjie Chen Hongguang Zhang Tingting Guo Yukang Yuan Liting Zhang Jun Wang Hui Zheng Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
description	LUBAC is involved in adding linear ubiquitin chains to important immune signaling proteins. Here the authors show that this mechanism is effective in inhibiting STAT1-mediated interferon signaling, and that the deubiquitinase OTULIN can remove these linear ubiquitins from STAT1 to reactivate this antiviral signaling pathway.
format	article
author	Yibo Zuo Qian Feng Lincong Jin Fan Huang Ying Miao Jin Liu Ying Xu Xiangjie Chen Hongguang Zhang Tingting Guo Yukang Yuan Liting Zhang Jun Wang Hui Zheng
author_facet	Yibo Zuo Qian Feng Lincong Jin Fan Huang Ying Miao Jin Liu Ying Xu Xiangjie Chen Hongguang Zhang Tingting Guo Yukang Yuan Liting Zhang Jun Wang Hui Zheng
author_sort	Yibo Zuo
title	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
title_short	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
title_full	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
title_fullStr	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
title_full_unstemmed	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling
title_sort	regulation of the linear ubiquitination of stat1 controls antiviral interferon signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c4454e0aa0248c9a214db9c6f0ed420
work_keys_str_mv	AT yibozuo regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT qianfeng regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT lincongjin regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT fanhuang regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT yingmiao regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT jinliu regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT yingxu regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT xiangjiechen regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT hongguangzhang regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT tingtingguo regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT yukangyuan regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT litingzhang regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT junwang regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling AT huizheng regulationofthelinearubiquitinationofstat1controlsantiviralinterferonsignaling
_version_	1718386958293532672

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling

Ejemplares similares