Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning

Abstract An increasing number of studies show that listeners often have difficulty hearing in situations with background noise, despite normal tuning curves in quiet. One potential source of this difficulty could be sensorineural changes in the auditory periphery (the ear). Signal in noise detection...

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Autores principales:	Yi Ye, Antje Ihlefeld, Merri J. Rosen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c4bd58708eb4a1cad401d1684eb6c41
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spelling	oai:doaj.org-article:4c4bd58708eb4a1cad401d1684eb6c412021-12-02T14:03:57ZConductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning10.1038/s41598-021-83115-12045-2322https://doaj.org/article/4c4bd58708eb4a1cad401d1684eb6c412021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83115-1https://doaj.org/toc/2045-2322Abstract An increasing number of studies show that listeners often have difficulty hearing in situations with background noise, despite normal tuning curves in quiet. One potential source of this difficulty could be sensorineural changes in the auditory periphery (the ear). Signal in noise detection deficits also arise in animals raised with developmental conductive hearing loss (CHL), a manipulation that induces acoustic attenuation to model how sound deprivation changes the central auditory system. This model attributes perceptual deficits to central changes by assuming that CHL does not affect sensorineural elements in the periphery that could raise masked thresholds. However, because of efferent feedback, altering the auditory system could affect cochlear elements. Indeed, recent studies show that adult-onset CHL can cause cochlear synapse loss, potentially calling into question the assumption of an intact periphery in early-onset CHL. To resolve this issue, we tested the long-term peripheral effects of CHL via developmental bilateral malleus displacement. Using forward masking tuning curves, we compared peripheral tuning in animals raised with CHL vs age-matched controls. Using compound action potential measurements from the round window, we assessed inner hair cell synapse integrity. Results indicate that developmental CHL can cause minor synaptopathy. However, developmental CHL does not appreciably alter peripheral frequency tuning.Yi YeAntje IhlefeldMerri J. RosenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Ye Antje Ihlefeld Merri J. Rosen Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
description	Abstract An increasing number of studies show that listeners often have difficulty hearing in situations with background noise, despite normal tuning curves in quiet. One potential source of this difficulty could be sensorineural changes in the auditory periphery (the ear). Signal in noise detection deficits also arise in animals raised with developmental conductive hearing loss (CHL), a manipulation that induces acoustic attenuation to model how sound deprivation changes the central auditory system. This model attributes perceptual deficits to central changes by assuming that CHL does not affect sensorineural elements in the periphery that could raise masked thresholds. However, because of efferent feedback, altering the auditory system could affect cochlear elements. Indeed, recent studies show that adult-onset CHL can cause cochlear synapse loss, potentially calling into question the assumption of an intact periphery in early-onset CHL. To resolve this issue, we tested the long-term peripheral effects of CHL via developmental bilateral malleus displacement. Using forward masking tuning curves, we compared peripheral tuning in animals raised with CHL vs age-matched controls. Using compound action potential measurements from the round window, we assessed inner hair cell synapse integrity. Results indicate that developmental CHL can cause minor synaptopathy. However, developmental CHL does not appreciably alter peripheral frequency tuning.
format	article
author	Yi Ye Antje Ihlefeld Merri J. Rosen
author_facet	Yi Ye Antje Ihlefeld Merri J. Rosen
author_sort	Yi Ye
title	Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
title_short	Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
title_full	Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
title_fullStr	Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
title_full_unstemmed	Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
title_sort	conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c4bd58708eb4a1cad401d1684eb6c41
work_keys_str_mv	AT yiye conductivehearinglossduringdevelopmentdoesnotappreciablyalterthesharpnessofcochleartuning AT antjeihlefeld conductivehearinglossduringdevelopmentdoesnotappreciablyalterthesharpnessofcochleartuning AT merrijrosen conductivehearinglossduringdevelopmentdoesnotappreciablyalterthesharpnessofcochleartuning
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Conductive hearing loss during development does not appreciably alter the sharpness of cochlear tuning

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