Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages

Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evol...

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Autores principales:	Shichao Pang, Yidi Sun, Leilei Wu, Liguang Yang, Yi-Lei Zhao, Zhen Wang, Yixue Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea
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spelling	oai:doaj.org-article:4c4f24f4e1ce4ac6b67c36ad432f09ea2021-12-02T15:07:48ZReconstruction of kidney renal clear cell carcinoma evolution across pathological stages10.1038/s41598-018-20321-42045-2322https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20321-4https://doaj.org/toc/2045-2322Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.Shichao PangYidi SunLeilei WuLiguang YangYi-Lei ZhaoZhen WangYixue LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shichao Pang Yidi Sun Leilei Wu Liguang Yang Yi-Lei Zhao Zhen Wang Yixue Li Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
description	Abstract Although numerous studies on kidney renal clear cell carcinoma (KIRC) were carried out, the dynamic process of tumor formation was not clear yet. Inadequate attention was paid on the evolutionary paths among somatic mutations and their clinical implications. As the tumor initiation and evolution of KIRC were primarily associated with SNVs, we reconstructed an evolutionary process of KIRC using cross-sectional SNVs in different pathological stages. KIRC driver genes appeared early in the evolutionary tree, and the genes with moderate mutation frequency showed a pattern of stage-by-stage expansion. Although the individual gene mutations were not necessarily associated with survival outcome, the evolutionary paths such as VHL-PBRM1 and FMN2-PCLO could indicate stage-specific prognosis. Our results suggested that, besides mutation frequency, the evolutionary relationship among the mutated genes could facilitate to identify novel drivers and biomarkers for clinical utility.
format	article
author	Shichao Pang Yidi Sun Leilei Wu Liguang Yang Yi-Lei Zhao Zhen Wang Yixue Li
author_facet	Shichao Pang Yidi Sun Leilei Wu Liguang Yang Yi-Lei Zhao Zhen Wang Yixue Li
author_sort	Shichao Pang
title	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_short	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_full	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_fullStr	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_full_unstemmed	Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
title_sort	reconstruction of kidney renal clear cell carcinoma evolution across pathological stages
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4c4f24f4e1ce4ac6b67c36ad432f09ea
work_keys_str_mv	AT shichaopang reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT yidisun reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT leileiwu reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT liguangyang reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT yileizhao reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT zhenwang reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages AT yixueli reconstructionofkidneyrenalclearcellcarcinomaevolutionacrosspathologicalstages
_version_	1718388382451630080

Reconstruction of kidney renal clear cell carcinoma evolution across pathological stages

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