Imaging body composition in obesity and weight loss: challenges and opportunities

Heidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a...

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Autores principales:	Silver HJ, Welch B, Avison MJ, Niswender KD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	imaging body composition obesity magnetic resonance imaging fat-water imaging Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4c4f8adb169c4295a90190cbb4884850
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spelling	oai:doaj.org-article:4c4f8adb169c4295a90190cbb48848502021-12-02T00:41:57ZImaging body composition in obesity and weight loss: challenges and opportunities1178-7007https://doaj.org/article/4c4f8adb169c4295a90190cbb48848502010-09-01T00:00:00Zhttps://www.dovepress.com/imaging-body-composition-in-obesity-and-weight-loss-challenges-and-opp-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Heidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a threat to public health worldwide primarily due to the comorbidities related to visceral adiposity, inflammation, and insulin resistance that increase risk for type 2 diabetes and cardiovascular disease. The translational research portfolio that originally described these risk factors was significantly enhanced by imaging techniques, such as dual-energy X-ray absorptiometry (DEXA), computed tomography (CT), and magnetic resonance imaging (MRI). In this article, we briefly review the important contributions of these techniques to understand the role of body composition in the pathogenesis of obesity-related complications. Notably, these imaging techniques have contributed greatly to recent findings identifying gender and racial differences in body composition and patterns of body composition change during weight loss. Although these techniques have the ability to generate good-quality body composition data, each possesses limitations. For example, DEXA is unable to differentiate type of fat, CT has better resolution but provides greater ionizing radiation exposure, and MRI tends to require longer imaging times and specialized equipment for acquisition and analysis. With the serious need for efficacious and cost-effective therapies to appropriately identify and treat at-risk obese individuals, there is greater need for translational tools that can further elucidate the interplay between body composition and the metabolic aberrations associated with obesity. In conclusion, we will offer our perspective on the evolution toward an ideal imaging method for body composition assessment in obesity and weight loss, and the challenges remaining to achieve this goal.Keywords: obesity, imaging, body composition, visceral fatSilver HJWelch BAvison MJNiswender KDDove Medical Pressarticleimagingbody compositionobesitymagnetic resonance imagingfat-water imagingSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 337-347 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	imaging body composition obesity magnetic resonance imaging fat-water imaging Specialties of internal medicine RC581-951
spellingShingle	imaging body composition obesity magnetic resonance imaging fat-water imaging Specialties of internal medicine RC581-951 Silver HJ Welch B Avison MJ Niswender KD Imaging body composition in obesity and weight loss: challenges and opportunities
description	Heidi J Silver1, E Brian Welch2, Malcolm J Avison2, Kevin D Niswender1,31Department of Medicine, 2Department of Radiology and Radiological Sciences, Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, USA; 3Tennessee Valley Healthcare System, Nashville, TN, USAAbstract: Obesity is a threat to public health worldwide primarily due to the comorbidities related to visceral adiposity, inflammation, and insulin resistance that increase risk for type 2 diabetes and cardiovascular disease. The translational research portfolio that originally described these risk factors was significantly enhanced by imaging techniques, such as dual-energy X-ray absorptiometry (DEXA), computed tomography (CT), and magnetic resonance imaging (MRI). In this article, we briefly review the important contributions of these techniques to understand the role of body composition in the pathogenesis of obesity-related complications. Notably, these imaging techniques have contributed greatly to recent findings identifying gender and racial differences in body composition and patterns of body composition change during weight loss. Although these techniques have the ability to generate good-quality body composition data, each possesses limitations. For example, DEXA is unable to differentiate type of fat, CT has better resolution but provides greater ionizing radiation exposure, and MRI tends to require longer imaging times and specialized equipment for acquisition and analysis. With the serious need for efficacious and cost-effective therapies to appropriately identify and treat at-risk obese individuals, there is greater need for translational tools that can further elucidate the interplay between body composition and the metabolic aberrations associated with obesity. In conclusion, we will offer our perspective on the evolution toward an ideal imaging method for body composition assessment in obesity and weight loss, and the challenges remaining to achieve this goal.Keywords: obesity, imaging, body composition, visceral fat
format	article
author	Silver HJ Welch B Avison MJ Niswender KD
author_facet	Silver HJ Welch B Avison MJ Niswender KD
author_sort	Silver HJ
title	Imaging body composition in obesity and weight loss: challenges and opportunities
title_short	Imaging body composition in obesity and weight loss: challenges and opportunities
title_full	Imaging body composition in obesity and weight loss: challenges and opportunities
title_fullStr	Imaging body composition in obesity and weight loss: challenges and opportunities
title_full_unstemmed	Imaging body composition in obesity and weight loss: challenges and opportunities
title_sort	imaging body composition in obesity and weight loss: challenges and opportunities
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/4c4f8adb169c4295a90190cbb4884850
work_keys_str_mv	AT silverhj imagingbodycompositioninobesityandweightlosschallengesandopportunities AT welchb imagingbodycompositioninobesityandweightlosschallengesandopportunities AT avisonmj imagingbodycompositioninobesityandweightlosschallengesandopportunities AT niswenderkd imagingbodycompositioninobesityandweightlosschallengesandopportunities
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Imaging body composition in obesity and weight loss: challenges and opportunities

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