Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease

Abstract Exercise is beneficial to cardiovascular health, evidenced by reduced post-exercise central aortic blood pressure (BP) and wave reflection. We assessed if post-exercise central hemodynamics are modified due to an altered thermal state related to exercise in the cold in patients with coronar...

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Autores principales:	Heidi E. Hintsala, Rasmus I. P. Valtonen, Antti Kiviniemi, Craig Crandall, Juha Perkiömäki, Arto Hautala, Matti Mäntysaari, Markku Alén, Niilo Ryti, Jouni J. K. Jaakkola, Tiina M. Ikäheimo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c529caa6aa44469a88558e72660e8c2
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spelling	oai:doaj.org-article:4c529caa6aa44469a88558e72660e8c22021-12-02T13:24:26ZCentral aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease10.1038/s41598-021-82155-x2045-2322https://doaj.org/article/4c529caa6aa44469a88558e72660e8c22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82155-xhttps://doaj.org/toc/2045-2322Abstract Exercise is beneficial to cardiovascular health, evidenced by reduced post-exercise central aortic blood pressure (BP) and wave reflection. We assessed if post-exercise central hemodynamics are modified due to an altered thermal state related to exercise in the cold in patients with coronary artery disease (CAD). CAD patients (n = 11) performed moderate-intensity lower-body exercise (walking at 65–70% of HRmax) and rested in neutral (+ 22 °C) and cold (− 15 °C) conditions. In another protocol, CAD patients (n = 15) performed static (five 1.5 min work cycles, 10–30% of maximal voluntary contraction) and dynamic (three 5 min workloads, 56–80% of HRmax) upper-body exercise at the same temperatures. Both datasets consisted of four 30-min exposures administered in random order. Central aortic BP and augmentation index (AI) were noninvasively assessed via pulse wave analyses prior to and 25 min after these interventions. Lower-body dynamic exercise decreased post-exercise central systolic BP (6–10 mmHg, p < 0.001) and AI (1–6%, p < 0.001) both after cold and neutral and conditions. Dynamic upper-body exercise lowered central systolic BP (2–4 mmHg, p < 0.001) after exposure to both temperatures. In contrast, static upper-body exercise increased central systolic BP after exposure to cold (7 ± 6 mmHg, p < 0.001). Acute dynamic lower and upper-body exercise mainly lowers post-exercise central BP in CAD patients irrespective of the environmental temperature. In contrast, central systolic BP was elevated after static exercise in cold. CAD patients likely benefit from year-round dynamic exercise, but hemodynamic responses following static exercise in a cold environment should be examined further. Clinical trials.gov: NCT02855905 04/08/2016.Heidi E. HintsalaRasmus I. P. ValtonenAntti KiviniemiCraig CrandallJuha PerkiömäkiArto HautalaMatti MäntysaariMarkku AlénNiilo RytiJouni J. K. JaakkolaTiina M. IkäheimoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heidi E. Hintsala Rasmus I. P. Valtonen Antti Kiviniemi Craig Crandall Juha Perkiömäki Arto Hautala Matti Mäntysaari Markku Alén Niilo Ryti Jouni J. K. Jaakkola Tiina M. Ikäheimo Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
description	Abstract Exercise is beneficial to cardiovascular health, evidenced by reduced post-exercise central aortic blood pressure (BP) and wave reflection. We assessed if post-exercise central hemodynamics are modified due to an altered thermal state related to exercise in the cold in patients with coronary artery disease (CAD). CAD patients (n = 11) performed moderate-intensity lower-body exercise (walking at 65–70% of HRmax) and rested in neutral (+ 22 °C) and cold (− 15 °C) conditions. In another protocol, CAD patients (n = 15) performed static (five 1.5 min work cycles, 10–30% of maximal voluntary contraction) and dynamic (three 5 min workloads, 56–80% of HRmax) upper-body exercise at the same temperatures. Both datasets consisted of four 30-min exposures administered in random order. Central aortic BP and augmentation index (AI) were noninvasively assessed via pulse wave analyses prior to and 25 min after these interventions. Lower-body dynamic exercise decreased post-exercise central systolic BP (6–10 mmHg, p < 0.001) and AI (1–6%, p < 0.001) both after cold and neutral and conditions. Dynamic upper-body exercise lowered central systolic BP (2–4 mmHg, p < 0.001) after exposure to both temperatures. In contrast, static upper-body exercise increased central systolic BP after exposure to cold (7 ± 6 mmHg, p < 0.001). Acute dynamic lower and upper-body exercise mainly lowers post-exercise central BP in CAD patients irrespective of the environmental temperature. In contrast, central systolic BP was elevated after static exercise in cold. CAD patients likely benefit from year-round dynamic exercise, but hemodynamic responses following static exercise in a cold environment should be examined further. Clinical trials.gov: NCT02855905 04/08/2016.
format	article
author	Heidi E. Hintsala Rasmus I. P. Valtonen Antti Kiviniemi Craig Crandall Juha Perkiömäki Arto Hautala Matti Mäntysaari Markku Alén Niilo Ryti Jouni J. K. Jaakkola Tiina M. Ikäheimo
author_facet	Heidi E. Hintsala Rasmus I. P. Valtonen Antti Kiviniemi Craig Crandall Juha Perkiömäki Arto Hautala Matti Mäntysaari Markku Alén Niilo Ryti Jouni J. K. Jaakkola Tiina M. Ikäheimo
author_sort	Heidi E. Hintsala
title	Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
title_short	Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
title_full	Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
title_fullStr	Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
title_full_unstemmed	Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
title_sort	central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c529caa6aa44469a88558e72660e8c2
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Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease

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