Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells

Abstract Serotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT1–7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging innate and adaptive immune responses via their vast repertoire of p...

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Autores principales:	Attila Szabo, Peter Gogolak, Gabor Koncz, Zsofia Foldvari, Kitti Pazmandi, Noemi Miltner, Szilard Poliska, Attila Bacsi, Srdjan Djurovic, Eva Rajnavolgyi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c54e4788ff54e838671ed8807ac1ce7
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spelling	oai:doaj.org-article:4c54e4788ff54e838671ed8807ac1ce72021-12-02T15:08:50ZImmunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells10.1038/s41598-018-20173-y2045-2322https://doaj.org/article/4c54e4788ff54e838671ed8807ac1ce72018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20173-yhttps://doaj.org/toc/2045-2322Abstract Serotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT1–7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging innate and adaptive immune responses via their vast repertoire of pattern recognition receptors and antigen-presenting capability. Although serotonin is known to influence immunity at many levels, cell type-specific expression and function of its receptors remains poorly understood. Here we aimed to study 5-HT1–7 expression and function in CD1a− and CD1a+ human monocyte-derived DCs (moDCs). We found that the 5-HT2B receptor-subtype is solely expressed by the inflammatory CD1a+ moDC subset. Specific 5-HT2B activation potently inhibited TLR2, TLR3, and TLR7/8-induced proinflammatory cytokine and chemokine (TNF-α, IL-6, IL-8, IP-10, IL-12) but not type I interferon-β responses. 5-HT2B agonism also interfered with the polarization of CD1a+ moDC-primed CD4+ T cells towards inflammatory Th1 and Th17 effector lymphocytes. Here we report the subset-specific expression and immunomodulatory function of 5-HT2B in human moDCs. Our results expand the biological role of 5-HT2B which may act not only as a neurotransmitter receptor, but also as an important modulator of both innate and adaptive immune responses.Attila SzaboPeter GogolakGabor KonczZsofia FoldvariKitti PazmandiNoemi MiltnerSzilard PoliskaAttila BacsiSrdjan DjurovicEva RajnavolgyiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Attila Szabo Peter Gogolak Gabor Koncz Zsofia Foldvari Kitti Pazmandi Noemi Miltner Szilard Poliska Attila Bacsi Srdjan Djurovic Eva Rajnavolgyi Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
description	Abstract Serotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT1–7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging innate and adaptive immune responses via their vast repertoire of pattern recognition receptors and antigen-presenting capability. Although serotonin is known to influence immunity at many levels, cell type-specific expression and function of its receptors remains poorly understood. Here we aimed to study 5-HT1–7 expression and function in CD1a− and CD1a+ human monocyte-derived DCs (moDCs). We found that the 5-HT2B receptor-subtype is solely expressed by the inflammatory CD1a+ moDC subset. Specific 5-HT2B activation potently inhibited TLR2, TLR3, and TLR7/8-induced proinflammatory cytokine and chemokine (TNF-α, IL-6, IL-8, IP-10, IL-12) but not type I interferon-β responses. 5-HT2B agonism also interfered with the polarization of CD1a+ moDC-primed CD4+ T cells towards inflammatory Th1 and Th17 effector lymphocytes. Here we report the subset-specific expression and immunomodulatory function of 5-HT2B in human moDCs. Our results expand the biological role of 5-HT2B which may act not only as a neurotransmitter receptor, but also as an important modulator of both innate and adaptive immune responses.
format	article
author	Attila Szabo Peter Gogolak Gabor Koncz Zsofia Foldvari Kitti Pazmandi Noemi Miltner Szilard Poliska Attila Bacsi Srdjan Djurovic Eva Rajnavolgyi
author_facet	Attila Szabo Peter Gogolak Gabor Koncz Zsofia Foldvari Kitti Pazmandi Noemi Miltner Szilard Poliska Attila Bacsi Srdjan Djurovic Eva Rajnavolgyi
author_sort	Attila Szabo
title	Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
title_short	Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
title_full	Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
title_fullStr	Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
title_full_unstemmed	Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells
title_sort	immunomodulatory capacity of the serotonin receptor 5-ht2b in a subset of human dendritic cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4c54e4788ff54e838671ed8807ac1ce7
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Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells

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