INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS
Abstract. During the passage through the utero-placental circulation, peripheral blood monocytes are exposed to action of various soluble placenta-derived factors. Subsequently these cells migrate to placental tissue and play a key role in regulation of placental growth and development. We investiga...
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oai:doaj.org-article:4c55893b68364ef0962a6703933406102021-11-18T08:03:43ZINFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS1563-06252313-741X10.15789/1563-0625-2013-5-449-456https://doaj.org/article/4c55893b68364ef0962a6703933406102014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/661https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. During the passage through the utero-placental circulation, peripheral blood monocytes are exposed to action of various soluble placenta-derived factors. Subsequently these cells migrate to placental tissue and play a key role in regulation of placental growth and development. We investigated the influence of placental secretory factors upon expression of THP-1 cells surface receptors during normal pregnancy, and pregnancy complicated with preeclampsia. Soluble placenta-derived factors produced by the third-trimester placenta caused reduced intensity of CD11а, CD18, CD54, CD14, TRAIL and VEGFR1 expression on THP-1 cells, as compared with the first-trimester placental extracts. Soluble placenta-derived factors from preeclamptic placenta caused an increased intensity of CD18 and CD54 expression by THP-1 cells and decreased intensity of VEGFR1 expression in comparison to normal pregnancy. The work was supported by grants of the President of the Russian Federation № НШ-131.2012.7, СП-3492.2013.4 МК-1580.2013.7 and by grant РФФИ № 13-04-00304 А.T. Yu. LvovaYa. S. OnochinaD. A. KorenkovO. I. StepanovaK. N. FuraevaE. A. PotolicinaS. A. SelkovD. I. SokolovSPb RAACIarticlemonocytemacrophagesplacentapreeclampsiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 449-456 (2014) |
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DOAJ |
| collection |
DOAJ |
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RU |
| topic |
monocyte macrophages placenta preeclampsia Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
monocyte macrophages placenta preeclampsia Immunologic diseases. Allergy RC581-607 T. Yu. Lvova Ya. S. Onochina D. A. Korenkov O. I. Stepanova K. N. Furaeva E. A. Potolicina S. A. Selkov D. I. Sokolov INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| description |
Abstract. During the passage through the utero-placental circulation, peripheral blood monocytes are exposed to action of various soluble placenta-derived factors. Subsequently these cells migrate to placental tissue and play a key role in regulation of placental growth and development. We investigated the influence of placental secretory factors upon expression of THP-1 cells surface receptors during normal pregnancy, and pregnancy complicated with preeclampsia. Soluble placenta-derived factors produced by the third-trimester placenta caused reduced intensity of CD11а, CD18, CD54, CD14, TRAIL and VEGFR1 expression on THP-1 cells, as compared with the first-trimester placental extracts. Soluble placenta-derived factors from preeclamptic placenta caused an increased intensity of CD18 and CD54 expression by THP-1 cells and decreased intensity of VEGFR1 expression in comparison to normal pregnancy. The work was supported by grants of the President of the Russian Federation № НШ-131.2012.7, СП-3492.2013.4 МК-1580.2013.7 and by grant РФФИ № 13-04-00304 А. |
| format |
article |
| author |
T. Yu. Lvova Ya. S. Onochina D. A. Korenkov O. I. Stepanova K. N. Furaeva E. A. Potolicina S. A. Selkov D. I. Sokolov |
| author_facet |
T. Yu. Lvova Ya. S. Onochina D. A. Korenkov O. I. Stepanova K. N. Furaeva E. A. Potolicina S. A. Selkov D. I. Sokolov |
| author_sort |
T. Yu. Lvova |
| title |
INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| title_short |
INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| title_full |
INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| title_fullStr |
INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| title_full_unstemmed |
INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS |
| title_sort |
influence of soluble placentaderived factors upon expression of surface receptors on thp-1 cells |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/4c55893b68364ef0962a670393340610 |
| work_keys_str_mv |
AT tyulvova influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT yasonochina influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT dakorenkov influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT oistepanova influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT knfuraeva influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT eapotolicina influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT saselkov influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells AT disokolov influenceofsolubleplacentaderivedfactorsuponexpressionofsurfacereceptorsonthp1cells |
| _version_ |
1718422414923137024 |