Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors

Adrenocortical cancer (ACC) is a rarely diagnosed and aggressive cancer whose metastatic form has been scarcely studied. Here, the authors study primary and metastatic ACC to investigate genomic heterogeneity, discovering higher mutation rates in metastatic lesions and novel recurrent mutations.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sudheer Kumar Gara, Justin Lack, Lisa Zhang, Emerson Harris, Margaret Cam, Electron Kebebew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c5675233ee343b3b700e4345c1632f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4c5675233ee343b3b700e4345c1632f9
record_format	dspace
spelling	oai:doaj.org-article:4c5675233ee343b3b700e4345c1632f92021-12-02T16:56:39ZMetastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors10.1038/s41467-018-06366-z2041-1723https://doaj.org/article/4c5675233ee343b3b700e4345c1632f92018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06366-zhttps://doaj.org/toc/2041-1723Adrenocortical cancer (ACC) is a rarely diagnosed and aggressive cancer whose metastatic form has been scarcely studied. Here, the authors study primary and metastatic ACC to investigate genomic heterogeneity, discovering higher mutation rates in metastatic lesions and novel recurrent mutations.Sudheer Kumar GaraJustin LackLisa ZhangEmerson HarrisMargaret CamElectron KebebewNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sudheer Kumar Gara Justin Lack Lisa Zhang Emerson Harris Margaret Cam Electron Kebebew Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
description	Adrenocortical cancer (ACC) is a rarely diagnosed and aggressive cancer whose metastatic form has been scarcely studied. Here, the authors study primary and metastatic ACC to investigate genomic heterogeneity, discovering higher mutation rates in metastatic lesions and novel recurrent mutations.
format	article
author	Sudheer Kumar Gara Justin Lack Lisa Zhang Emerson Harris Margaret Cam Electron Kebebew
author_facet	Sudheer Kumar Gara Justin Lack Lisa Zhang Emerson Harris Margaret Cam Electron Kebebew
author_sort	Sudheer Kumar Gara
title	Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
title_short	Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
title_full	Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
title_fullStr	Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
title_full_unstemmed	Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
title_sort	metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4c5675233ee343b3b700e4345c1632f9
work_keys_str_mv	AT sudheerkumargara metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors AT justinlack metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors AT lisazhang metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors AT emersonharris metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors AT margaretcam metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors AT electronkebebew metastaticadrenocorticalcarcinomadisplayshighermutationrateandtumorheterogeneitythanprimarytumors
_version_	1718382737352556544

Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors

Ejemplares similares