Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology

Ketamine is a general anesthetic that is used also as an anti-depressant, but its use is associated with cystitis. Here, the authors show that ketamine is an antagonist of the Cav1.2 channel in bladder smooth muscle cells, that ablation of this channel in mice mimics the cystitis induced by ketamine...

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Autores principales:	Huan Chen, David H. Vandorpe, Xiang Xie, Seth L. Alper, Mark L. Zeidel, Weiqun Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c6049dad79c426db90368daaeea5f52
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spelling	oai:doaj.org-article:4c6049dad79c426db90368daaeea5f522021-12-02T15:09:26ZDisruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology10.1038/s41467-020-18167-42041-1723https://doaj.org/article/4c6049dad79c426db90368daaeea5f522020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18167-4https://doaj.org/toc/2041-1723Ketamine is a general anesthetic that is used also as an anti-depressant, but its use is associated with cystitis. Here, the authors show that ketamine is an antagonist of the Cav1.2 channel in bladder smooth muscle cells, that ablation of this channel in mice mimics the cystitis induced by ketamine, and show that this effect can be abrogated by an agonist of this ion channel.Huan ChenDavid H. VandorpeXiang XieSeth L. AlperMark L. ZeidelWeiqun YuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Chen David H. Vandorpe Xiang Xie Seth L. Alper Mark L. Zeidel Weiqun Yu Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
description	Ketamine is a general anesthetic that is used also as an anti-depressant, but its use is associated with cystitis. Here, the authors show that ketamine is an antagonist of the Cav1.2 channel in bladder smooth muscle cells, that ablation of this channel in mice mimics the cystitis induced by ketamine, and show that this effect can be abrogated by an agonist of this ion channel.
format	article
author	Huan Chen David H. Vandorpe Xiang Xie Seth L. Alper Mark L. Zeidel Weiqun Yu
author_facet	Huan Chen David H. Vandorpe Xiang Xie Seth L. Alper Mark L. Zeidel Weiqun Yu
author_sort	Huan Chen
title	Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
title_short	Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
title_full	Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
title_fullStr	Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
title_full_unstemmed	Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology
title_sort	disruption of cav1.2-mediated signaling is a pathway for ketamine-induced pathology
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c6049dad79c426db90368daaeea5f52
work_keys_str_mv	AT huanchen disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology AT davidhvandorpe disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology AT xiangxie disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology AT sethlalper disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology AT marklzeidel disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology AT weiqunyu disruptionofcav12mediatedsignalingisapathwayforketamineinducedpathology
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Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology

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