Serum methylarginines and spirometry-measured lung function in older adults.

<h4>Rationale</h4>Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.<h4>Objectives</h4>Thi...

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Autores principales:	Mark A McEvoy, Peter W Schofield, Wayne T Smith, Kingsley Agho, Arduino A Mangoni, Roy L Soiza, Roseanne Peel, Stephen J Hancock, Ciriaco Carru, Angelo Zinellu, John R Attia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c60f233f3d947389f1f2663baccfdbd
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spelling	oai:doaj.org-article:4c60f233f3d947389f1f2663baccfdbd2021-11-18T07:45:44ZSerum methylarginines and spirometry-measured lung function in older adults.1932-620310.1371/journal.pone.0058390https://doaj.org/article/4c60f233f3d947389f1f2663baccfdbd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23690915/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.<h4>Objectives</h4>This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.<h4>Methods</h4>Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.<h4>Measurements and main results</h4>In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.<h4>Conclusions</h4>After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.Mark A McEvoyPeter W SchofieldWayne T SmithKingsley AghoArduino A MangoniRoy L SoizaRoseanne PeelStephen J HancockCiriaco CarruAngelo ZinelluJohn R AttiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e58390 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark A McEvoy Peter W Schofield Wayne T Smith Kingsley Agho Arduino A Mangoni Roy L Soiza Roseanne Peel Stephen J Hancock Ciriaco Carru Angelo Zinellu John R Attia Serum methylarginines and spirometry-measured lung function in older adults.
description	<h4>Rationale</h4>Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.<h4>Objectives</h4>This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.<h4>Methods</h4>Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.<h4>Measurements and main results</h4>In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.<h4>Conclusions</h4>After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.
format	article
author	Mark A McEvoy Peter W Schofield Wayne T Smith Kingsley Agho Arduino A Mangoni Roy L Soiza Roseanne Peel Stephen J Hancock Ciriaco Carru Angelo Zinellu John R Attia
author_facet	Mark A McEvoy Peter W Schofield Wayne T Smith Kingsley Agho Arduino A Mangoni Roy L Soiza Roseanne Peel Stephen J Hancock Ciriaco Carru Angelo Zinellu John R Attia
author_sort	Mark A McEvoy
title	Serum methylarginines and spirometry-measured lung function in older adults.
title_short	Serum methylarginines and spirometry-measured lung function in older adults.
title_full	Serum methylarginines and spirometry-measured lung function in older adults.
title_fullStr	Serum methylarginines and spirometry-measured lung function in older adults.
title_full_unstemmed	Serum methylarginines and spirometry-measured lung function in older adults.
title_sort	serum methylarginines and spirometry-measured lung function in older adults.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4c60f233f3d947389f1f2663baccfdbd
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Serum methylarginines and spirometry-measured lung function in older adults.

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